Institut national de la santé et de la recherche médicale (Inserm), Institut de recherche en santé, environnement et travail (Irset - Inserm UMR 1085), F-35043 Rennes, France; Université de Rennes 1, Structure fédérative de recherche Biosit, UMS CNRS 3480/US Inserm 018, F 35043 Rennes, France.
INRA UMR 1331 ToxAlim (Research Center in Food Toxicology), University of Toulouse ENVT, INP, UPS, 180 Chemin de Tournefeuille, F-31027, France.
Semin Cancer Biol. 2017 Apr;43:49-65. doi: 10.1016/j.semcancer.2017.01.001. Epub 2017 Jan 11.
According to the World Health Organization, around 20% of all cancers would be due to environmental factors. Among these factors, several chemicals are indeed well recognized carcinogens. The widespread contaminant benzo[a]pyrene (B[a]P), an often used model carcinogen of the polycyclic aromatic hydrocarbons' family, has been suggested to target most, if not all, cancer hallmarks described by Hanahan and Weinberg. It is classified as a group I carcinogen by the International Agency for Research on Cancer; however, the precise intracellular mechanisms underlying its carcinogenic properties remain yet to be thoroughly defined. Recently, the pH homeostasis, a well known regulator of carcinogenic processes, was suggested to be a key actor in both cell death and Warburg-like metabolic reprogramming induced upon B[a]P exposure. The present review will highlight those data with the aim of favoring research on the role of H dynamics in environmental carcinogenesis.
据世界卫生组织（WHO）称，约 20%的癌症是由环境因素引起的。在这些因素中，有几种化学物质确实是公认的致癌物质。广泛存在的污染物苯并[a]芘（B[a]P）是多环芳烃家族中常用的模式致癌物质，据推测，它针对的是 Hanahan 和 Weinberg 所描述的几乎所有癌症特征。国际癌症研究机构（IARC）将其归类为 I 类致癌物；然而，其致癌特性的确切细胞内机制仍有待彻底定义。最近，pH 稳态，一种已知的致癌过程调节剂，被认为是苯并[a]芘暴露诱导细胞死亡和类似沃伯格的代谢重编程的关键因素。本综述将重点介绍这些数据，旨在促进对 H 动力学在环境致癌中的作用的研究。
