Miguel L M, Okemy-Andissa N, N'jilo D, Mokondjimobe E, Moukassa D, Longo-Mbenza B, Abena A A
Faculté des sciences de la santé, université Marien-Ngouabi, 69 Brazzaville, République du Congo.
École normale supérieure, université Marien-Ngouabi, 69 Brazzaville, République du Congo.
Encephale. 2019 Nov;45(5):397-404. doi: 10.1016/j.encep.2019.05.003. Epub 2019 Jun 19.
To study the effects of prolonged administration of Dacryodes edulis (G. Don) H.J. Lam (HDE) fruit oil on the symptoms of anxiety and cognitive performance in mice.
Anxiolytic activity and effects of HDE (5 and 10 ml/kg) on cognitive performance were evaluated in male mice after oral administration for 45 days. Anxiolytic effects were investigated in open field test, elevated plus Maze and hole board test. The Morris Water Maze test was used to evaluate cognitive performance in mice. Efficacy of HDE (5 and 10 ml/kg) was compared with that of fluoxetine (2 mg/kg p.o).
HDE decreases the total distance traveled, significantly increases the number of adjustments and the number of entries in the central area of open field. In the elevated cross labyrinth test, HDE increases the number of entries and the time spent in the open arms. HDE significantly increases the number of head insertion into the holes. In the Morris Water Maze test, HDE reduces latency before finding the platform and increases the time spent in the target quadrant.
The results confirm anxiolytic effects and improved cognitive performance after prolonged oral administration of HDE in rodents.
研究长期给予可食猴面包树（Dacryodes edulis (G. Don) H.J. Lam，简称HDE）果油对小鼠焦虑症状和认知能力的影响。
对雄性小鼠口服给予HDE（5和10毫升/千克）45天后，评估其抗焦虑活性及对认知能力的影响。通过旷场试验、高架十字迷宫试验和洞板试验研究抗焦虑作用。采用莫里斯水迷宫试验评估小鼠的认知能力。将HDE（5和10毫升/千克）的功效与氟西汀（2毫克/千克口服）进行比较。
HDE减少了总行进距离，显著增加了旷场中央区域的调整次数和进入次数。在高架十字迷宫试验中，HDE增加了进入次数和在开放臂停留的时间。HDE显著增加了头部插入孔洞的次数。在莫里斯水迷宫试验中，HDE减少了找到平台前的潜伏期，并增加了在目标象限停留的时间。
结果证实了长期口服HDE对啮齿动物具有抗焦虑作用并改善了认知能力。
