Psychology Service, VA Boston Healthcare System, 150 S. Huntington Ave, Boston, MA 02130, United States; Department of Psychiatry, Boston University School of Medicine, 72 E. Concord Street, Boston, MA 02118, United States; Department of Psychiatry, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, United States.
Research Service, VA Boston Healthcare System, 150 S. Huntington Ave, Boston, MA 02130, United States.
Clin Psychol Rev. 2019 Aug;72:101747. doi: 10.1016/j.cpr.2019.101747. Epub 2019 Jun 13.
There are well-known associations between PTSD and neurocognition, however, the direction of causality between the two is not well-understood. Neurocognition may alter risk of the development and maintenance of PTSD. Conversely, PTSD may pose risk to neurocognitive integrity. With cognitive and neurobiological conceptualizations of PTSD as a backdrop, this review will summarize results from several lines of research including preclinical, human analogue, retrospective, longitudinal, and treatment studies to inform the directional relationships between PTSD and neurocognition. Based on the collective findings from these related literatures, we suggest that a negative feedback loop between PTSD and neurocognition exists but that PTSD treatment and cognitive enhancement strategies may break this loop.
创伤后应激障碍（PTSD）与神经认知之间存在着众所周知的关联，但两者之间的因果关系尚不清楚。神经认知可能会改变 PTSD 的发展和维持风险。相反，PTSD 可能会对神经认知完整性构成风险。以 PTSD 的认知和神经生物学概念化为背景，本综述将总结包括临床前、人类模拟、回顾性、纵向和治疗研究在内的几条研究线的结果，以了解 PTSD 和神经认知之间的定向关系。基于这些相关文献的综合发现，我们认为 PTSD 和神经认知之间存在负反馈循环，但 PTSD 治疗和认知增强策略可能会打破这种循环。
