Shayo Sigfrid Casmir, Kawade Shigeru, Ogiso Kazuma, Yoshihiko Nishio
Department of Diabetes and Endocrine Medicine Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
Diabetes Metab Syndr. 2019 May-Jun;13(3):2164-2169. doi: 10.1016/j.dsx.2019.05.005. Epub 2019 May 14.
There is a paucity of aggregated clinical trials on strategies of ameliorating endothelial dysfunction associated with Metabolic Syndrome (MS). We reviewed clinical trials conducted between 2008 and 2017, reporting on strategies of improving endothelial function in patients with MS. A comprehensive search of published articles by the Google Scholar and PubMed were carried out. Only studies involving non-invasive, objective measurement of endothelial function were included. Thirty (30) studies were selected for analysis, in which physical exercise training, diet modification, calcium channel blockers + alpha-lipoic acid, bezafibrate, allopurinol, mesoglycan, and l-arginine supplementation significantly improved Endothelial-Dependent Vasodilation (EDV) in patients with MS but without cardiovascular diseases. Large multicenter clinical trials are required to address the question of generalizability of these findings.
关于改善与代谢综合征（MS）相关的内皮功能障碍策略的汇总临床试验较少。我们回顾了2008年至2017年间进行的临床试验，这些试验报告了改善MS患者内皮功能的策略。通过谷歌学术和PubMed对已发表文章进行了全面检索。仅纳入涉及内皮功能非侵入性客观测量的研究。选择了30项研究进行分析，其中体育锻炼训练、饮食调整、钙通道阻滞剂+α-硫辛酸、苯扎贝特、别嘌醇、硫酸软骨素和补充L-精氨酸显著改善了无心血管疾病的MS患者的内皮依赖性血管舒张（EDV）。需要进行大型多中心临床试验来解决这些发现的普遍性问题。
