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胃癌组织芯片检测溶血磷脂酸受体-2（LPA2）和 Krüppel 样因子 5（KLF5）蛋白表达的临床意义。

Clinical Significance of Lysophosphatidic Acid Receptor-2 (LPA2) and Krüppel-Like Factor 5 (KLF5) Protein Expression Detected by Tissue Microarray in Gastric Adenocarcinoma.

机构信息

Department of Pathology, The Second People's Hospital of Jiuquan, Jiuquan, Gansu, China (mainland).

Departments of Oncology, Zhuji People's Hospital of Zhejiang Province, Zhuji, Zhejiang, China (mainland).

出版信息

Med Sci Monit. 2019 Jun 25;25:4705-4715. doi: 10.12659/MSM.916336.

DOI:10.12659/MSM.916336
PMID:31235682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6607942/
Abstract

BACKGROUND The aim of this study was to evaluate lysophosphatidic acid receptor-2 (LPA2) and Krüppel-like factor 5 (KLF5) protein expression in gastric adenocarcinoma and their correlation with patient clinicopathological characteristics and prognosis. MATERIAL AND METHODS Fifty-one gastric adenocarcinoma tissue samples, 21 gastric intraepithelial neoplasia (GIN) samples, and 13 normal gastric tissue samples were collected to test for LPA2 and KLF5 expression by tissue microarray and immunohistochemistry assay. LPA2 and KLF5 positive expression rate between gastric adenocarcinoma, GIN, and normal gastric tissue were compared. The relationship between LPA2 expression, KLF5 expression, and patients' clinicopathological characteristics and prognosis were evaluated. RESULTS The positive expression rate of LPA2 and KLF5 were statistical different in gastric adenocarcinoma, GIN, and normal gastric tissue (P<0.05). LPA2 positive expression was associated with tumor invasion depth, Lauren type, vascular invasion, local lymph node metastasis, and clinical stage (P<0.05). There was no correlation between LPA2 expression (hazard ratio [HR]=1.84, 95% confidence interval [CI]: 0.89-3.80, P>0.05), KLF5 expression (HR=1.13, 95% CI: 0.53-2.36, P>0.05), and gastric cancer patients' overall survival. CONCLUSIONS LPA2 and KLF5 protein expressions were differently expressed in gastric adenocarcinoma, GIN, and normal gastric tissue, and differences were correlated with patients' clinical characteristic. However, LPA2 and KLF5 expressions were not correlated with the patients' prognosis.

摘要

背景

本研究旨在评估溶脂酸受体-2（LPA2）和 Krüppel 样因子 5（KLF5）在胃腺癌中的蛋白表达及其与患者临床病理特征和预后的关系。

材料与方法

收集 51 例胃腺癌组织标本、21 例胃上皮内瘤变（GIN）组织标本和 13 例正常胃组织标本，通过组织微阵列和免疫组织化学检测 LPA2 和 KLF5 的表达。比较胃腺癌、GIN 和正常胃组织中 LPA2 和 KLF5 的阳性表达率。评估 LPA2 表达、KLF5 表达与患者临床病理特征和预后的关系。

结果

胃腺癌、GIN 和正常胃组织中 LPA2 和 KLF5 的阳性表达率存在统计学差异（P<0.05）。LPA2 阳性表达与肿瘤浸润深度、Lauren 分型、血管侵犯、局部淋巴结转移和临床分期有关（P<0.05）。LPA2 表达（风险比[HR]=1.84，95%置信区间[CI]：0.89-3.80，P>0.05）、KLF5 表达（HR=1.13，95%CI：0.53-2.36，P>0.05）与胃癌患者的总生存无相关性。

结论

LPA2 和 KLF5 蛋白在胃腺癌、GIN 和正常胃组织中的表达不同，差异与患者的临床特征相关。然而，LPA2 和 KLF5 的表达与患者的预后无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/528a/6607942/01627e5b6771/medscimonit-25-4705-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/528a/6607942/adfada27cc53/medscimonit-25-4705-g002.jpg
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