Department of Gastroenterology, Changhua Christian Hospital, Changhua, Taiwan.
Virchows Arch. 2011 Aug;459(2):161-6. doi: 10.1007/s00428-011-1111-0. Epub 2011 Jul 6.
Krűppel-like factors (KLFs), highly conserved zinc-finger proteins, play either anti- or pro-proliferation roles in different human cancers through regulating a wide range of genes' expression. Here, we investigated the expression of KLF5 in gastric cancers and its correlation with clinicopathological parameters and overall survival rates. In this study, KLF5 expression was measured by an immunohistochemical microarray assay of tissue taken from 76 surgical specimens. Higher KLF5 expression was significantly associated with lower tumor grade (P < 0.001). Nuclear staining of the KLF5 expression was significantly associated with a higher tumor grade (P = 0.000), higher clinical stage (P = 0.019), lymph node status (P = 0.016), and 2-year survival (P = 0.017). Patients with nuclear staining of KLF5 had a significantly lower disease-free survival rate compared to patients with negative nuclear staining, as defined by a log-rank test (P = 0.041). Our results revealed that KLF5 may play an oncogenetic role in gastric carcinogenesis.
Krüppel 样因子（KLFs）是高度保守的锌指蛋白，通过调节广泛的基因表达，在不同的人类癌症中发挥抗增殖或促增殖作用。在这里，我们研究了 KLF5 在胃癌中的表达及其与临床病理参数和总生存率的相关性。在这项研究中，我们通过对 76 个手术标本组织进行免疫组织化学微阵列分析来测量 KLF5 的表达。较高的 KLF5 表达与较低的肿瘤分级显著相关（P<0.001）。KLF5 表达的核染色与较高的肿瘤分级（P=0.000）、较高的临床分期（P=0.019）、淋巴结状态（P=0.016）和 2 年生存率（P=0.017）显著相关。通过对数秩检验（P=0.041）发现，与核染色阴性的患者相比，KLF5 核染色的患者无病生存率显著降低。我们的研究结果表明，KLF5 可能在胃癌发生中发挥致癌基因的作用。
