Department of Thoracic Surgery, The First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, People's Republic of China.
Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, No. 44 Xiaoheyan Road, Dadong, Shenyang, 110042, Liaoning, People's Republic of China.
Surg Endosc. 2020 Mar;34(3):1253-1260. doi: 10.1007/s00464-019-06889-6. Epub 2019 Jun 24.
Endoscopic sleeve gastroplasty (ESG) is a minimally invasive, effective, and safe technique for weight loss intervention. Since a relatively small number of cases were present in previous studies, this study aimed to elucidate the efficacy and safety of ESG.
Relevant publications were identified through searching PubMed, EMBASE, Cochrane, and Web of Science before March 1, 2019. The percentage of total body weight loss (%TBWL), percentage of excess weight loss (%EWL), and the adverse event rate in each follow-up session were extracted, pooled, and analyzed. Forest plots were graphed based on random effects models.
A total of 1542 patients from nine studies were eligible for analysis. The pooled results of %TBWL at 1, 3, 6, and 12 months were 8.78% (p = 0.000), 11.85% (p = 0.000), 14.47% (p = 0.024), and 16.09% (p = 0.063), respectively. The pooled results of %EWL at 1, 3, 6, and 12 months were 31.16% (p = 0.000), 43.61% (p = 0.000), 53.14% (p = 0.000), and 59.08% (p = 0.015), respectively. Finally, the pooled rate of mild adverse events was 72% (p < 0.01), and the pooled estimate of severe adverse events was only 1% (p = 0.08).
Although the conventional surgical sleeve gastrectomy is the gold standard for bariatric surgery, ESG could be a promising minimally invasive alternative for treating obesity with satisfactory efficacy and low risk.
内镜下袖状胃切除术（ESG）是一种微创、有效且安全的减肥干预技术。由于之前的研究中病例数量相对较少，本研究旨在阐明 ESG 的疗效和安全性。
通过检索 PubMed、EMBASE、Cochrane 和 Web of Science，在 2019 年 3 月 1 日之前确定相关出版物。提取、汇总并分析每个随访阶段的总体重减轻百分比（%TBWL）、超重减轻百分比（%EWL）和不良事件发生率。根据随机效应模型绘制森林图。
共有来自 9 项研究的 1542 名患者符合分析条件。1、3、6 和 12 个月时%TBWL 的汇总结果分别为 8.78%（p=0.000）、11.85%（p=0.000）、14.47%（p=0.024）和 16.09%（p=0.063）。1、3、6 和 12 个月时%EWL 的汇总结果分别为 31.16%（p=0.000）、43.61%（p=0.000）、53.14%（p=0.000）和 59.08%（p=0.015）。最后，轻度不良事件的汇总发生率为 72%（p<0.01），严重不良事件的汇总估计值仅为 1%（p=0.08）。
尽管传统的外科袖状胃切除术是减肥手术的金标准，但 ESG 可能是一种有前途的微创替代方法，用于治疗肥胖症，具有令人满意的疗效和低风险。
