Kumbhari Vivek, Hill Christine, Sullivan Shelby
aDivision of Gastroenterology and Hepatology, Department of Medicine, The Johns Hopkins Medical Institutions bDiversity Summer Internship Program, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland cDivision of Gastroenterology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Curr Opin Gastroenterol. 2017 Sep;33(5):358-365. doi: 10.1097/MOG.0000000000000383.
This review aims to present the current state of the field, highlight recent developments, and describe the clinical outcomes of these endoscopic bariatric and metabolic procedures.
There are an increasing number of devices and techniques that are available for the endoluminal treatment of obesity. It is now possible to offer FDA approved endoscopic therapies for patients with BMI as high as 55 kg/m. Although tremendous advances have been made, there is room for additional emphasis with regards to the metabolic improvements seen with these therapies, in addition to highlighting weight loss outcomes. Furthermore, for optimal outcomes, it is imperative that all endoluminal techniques are combined with at least a moderate intensity diet and lifestyle intervention for a minimum of 12 months.
This field bridges a gap between lifestyle counseling with or without pharmaceutical treatment and the most effective treatment of obesity, bariatric surgery. Owing to its minimally invasive nature, endoscopic metabolic and bariatric therapy has the potential to appeal patients who either do not qualify or do not want bariatric surgery and have not been adequately treated with medical therapy. In addition, these therapies may be beneficial early on in the onset of obesity.
本综述旨在呈现该领域的当前状况,突出近期进展,并描述这些内镜下减肥及代谢手术的临床结果。
可用于肥胖症腔内治疗的设备和技术越来越多。现在已能够为体重指数高达55kg/m²的患者提供经美国食品药品监督管理局批准的内镜治疗。尽管已取得巨大进展,但除了突出减肥效果外,对于这些疗法所带来的代谢改善仍有进一步强调的空间。此外,为获得最佳效果,所有腔内技术必须至少与中等强度的饮食和生活方式干预相结合,持续至少12个月。
该领域填补了有无药物治疗的生活方式咨询与最有效的肥胖症治疗方法——减肥手术之间的空白。由于其微创性质,内镜下代谢和减肥治疗有可能吸引那些不符合减肥手术条件或不想接受减肥手术且未通过药物治疗得到充分治疗的患者。此外,这些疗法在肥胖症发病早期可能有益。