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一名中年女性腹水的罕见病因——播散性结核伴腹膜炎

A Rare Cause of Ascites-Disseminated TB with Peritonitis in a Middle-Aged Female.

作者信息

Vithoosan Sahathevan, Shanjeeban Ponnudurai, Anpalahan Joseph Philip, Piranavan Paramarajan, Karunatilake Harindra, Jayanaga Ananda

机构信息

National Hospital, Colombo, Sri Lanka.

Internal Medicine, Saint Vincent Hospital, Worcester, MA 01608, USA.

出版信息

Case Rep Gastrointest Med. 2019 May 26;2019:5076857. doi: 10.1155/2019/5076857. eCollection 2019.

Abstract

BACKGROUND

Disseminated tuberculosis (TB) has been increasingly recognized in adults in the recent times due to increased prevalence of immune suppression. Here we describe a case of 47-year-old female who presented with disproportionate ascites where the diagnosis of disseminated TB was delayed.

CASE REPORT

A 47-year-old previously healthy female presented with generalised body swelling with disproportionate ascites and loss of appetite and weight for four-month duration. She denied any contact or past history of TB and reported no respiratory symptoms. Physical examination revealed significant ascites. There was no lymphadenopathy or hepatosplenomegaly. Respiratory system examination was normal. Her Erythrocyte Sedimentation Rate (ESR) was above 100. Tuberculin skin test was positive with 17mm. Contrast Enhanced Computed Tomography (CECT) abdomen revealed chronic liver disease with ascites. Diagnostic laparoscopy was in favour of miliary TB and the peritoneal biopsy revealed granulomatous inflammation with caseous necrosis, suggestive of TB. The patient was started on antituberculosis treatment and subsequently improved.

CONCLUSION

TB peritonitis due to disseminated TB should be considered in the differential diagnosis of disproportionate ascites. Even though the diagnosis is difficult, diagnostic laparoscopy and biopsy is very helpful. It is important to have an early diagnosis since delay in treatment can be detrimental in most cases.

摘要

背景

近年来,由于免疫抑制患病率增加,播散性结核病在成人中越来越受到认可。在此,我们描述一例47岁女性病例,该患者出现不成比例的腹水,播散性结核病的诊断被延迟。

病例报告

一名47岁既往健康的女性出现全身肿胀,伴有不成比例的腹水、食欲不振和体重减轻,持续4个月。她否认有任何结核病接触史或既往史,也未报告有呼吸道症状。体格检查发现有大量腹水。无淋巴结肿大或肝脾肿大。呼吸系统检查正常。她的红细胞沉降率(ESR)高于100。结核菌素皮肤试验阳性,硬结直径为17mm。腹部增强计算机断层扫描(CECT)显示慢性肝病伴腹水。诊断性腹腔镜检查支持粟粒性结核病,腹膜活检显示肉芽肿性炎症伴干酪样坏死,提示为结核病。患者开始接受抗结核治疗,随后病情好转。

结论

在不成比例腹水的鉴别诊断中应考虑播散性结核病引起的结核性腹膜炎。尽管诊断困难,但诊断性腹腔镜检查和活检非常有帮助。早期诊断很重要,因为在大多数情况下治疗延迟可能有害。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bae5/6556260/853fb4ecc7c6/CRIGM2019-5076857.001.jpg

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