Mayo Clinic, William J. von Liebig Center for Transplantation and Clinical Regeneration, Rochester, MN, USA.
The First Affiliated Hospital of China Medical University, Hepatobiliary Surgery, Shenyang, China.
Cell Transplant. 2019 Sep-Oct;28(9-10):1116-1122. doi: 10.1177/0963689719859262. Epub 2019 Jun 26.
Owing to the increasing worldwide burden of liver diseases, the crucial need for safe and effective interventions for treating end-stage liver failure has been a very productive line of inquiry in the discipline of hepatology for many years. Liver transplantation is recognized as the most effective treatment for end-stage liver disease; however, the shortage of donor organs, high medical costs, and lifelong use of immunosuppressive agents represent major drawbacks and demand exploration for alternative treatments. Stem cell-based therapies have been widely studied in the field of liver diseases and are considered to be among the most promising therapies. Herein, we review recent advances in the application of stem cell-related therapies in liver disease with the aim of providing readers with relevant knowledge in this field and inspiration to spur further inquiry.
由于全球范围内肝脏疾病负担不断增加，寻找安全有效的干预措施来治疗终末期肝衰竭一直是多年来肝病学领域非常活跃的研究方向。肝移植被认为是治疗终末期肝病最有效的方法；然而，供体器官短缺、高昂的医疗费用和终身使用免疫抑制剂等问题是其主要缺点，这就需要探索替代治疗方法。干细胞疗法在肝脏疾病领域已得到广泛研究，被认为是最有前途的治疗方法之一。本文综述了近年来干细胞相关疗法在肝脏疾病中的应用进展，旨在为读者提供该领域的相关知识，并激发进一步的研究。
