药物和其他外来化合物中毒患者的回顾性观察研究。

A retrospective observational study on patients intoxicated by drugs and other xenobiotics.

机构信息

Wroclaw Medical University, Wrocław, Poland (Faculty of Pharmacy with Division of Laboratory Diagnostics, Department of Toxicology).

Wroclaw Medical University, Wrocław, Poland (Students Science Club of Department of Toxicology).

出版信息

Int J Occup Med Environ Health. 2019 Jul 15;32(4):489-501. doi: 10.13075/ijomeh.1896.01344. Epub 2019 Jun 24.

DOI:10.13075/ijomeh.1896.01344

PMID:31241049

Abstract

OBJECTIVES

Many research studies conducted in various toxicology centers point to drugs as the most common cause of intoxication. Long-term observations make it possible to clarify the nature of these poisonings. The aim of this study was to examine the trends and reasons of intoxication in patients hospitalized over a 10-year observation period (2005-2015), as well as to compare the number of patients poisoned with nonsteroidal anti-inflammatory drugs (NSAIDs), mainly over-the-counter (OTC) drugs.

MATERIAL AND METHODS

A retrospective observational study examined the medical documentation of patients hospitalized in the Department of Toxicology and Internal Diseases of the T. Marciniak Lower Silesian Specialist Hospital in Wrocław in 2005-2015, including the analysis of the causes of intoxication as well as total poisoning-related death statistics. Quarterly and annual analyses of the numerical data, and comparisons of the frequency of poisonings were included. The patient population from the area of Lower Silesia, Poland, was examined.

RESULTS

The number of hospitalized patients has increased, with attempted suicide being the leading cause of death. Male intoxication and mortality have been found to predominate. Drugs are the most common cause of poisoning, and among these the most common are sedatives and psychotropic drugs. Intoxication due to NSAIDs, especially OTC drugs, increased significantly in the observation period. In 2005 no fatal cases were reported as a result of NSAID intoxication, while in 2015 mortality significantly increased to 43%.

CONCLUSIONS

The lack of a common trend in poisonings is observed but the number of hospitalized patients has increased, especially among young people, which is consistent with global trends. Drugs are the most common cause of mortality, and a significant increase in NSAID (mainly OTC) poisonings in particular indicates the growing prevalence of an uncontrolled use of these drugs. Int J Occup Med Environ Health. 2019;32(4):489-501.

摘要

目的

许多在不同毒理学中心进行的研究表明，药物是导致中毒的最常见原因。长期观察使我们能够澄清这些中毒的性质。本研究的目的是检查在 10 年观察期（2005-2015 年）住院的患者中毒的趋势和原因，并比较因非甾体抗炎药（NSAIDs）中毒的患者数量，主要是指非处方（OTC）药物。

材料与方法

回顾性观察性研究检查了 2005-2015 年期间在弗罗茨瓦夫 T.马钦尼亚克下西里西亚专业医院毒理学和内科住院的患者的医疗记录，包括中毒原因的分析以及与中毒相关的总死亡统计数据。包括对数值数据的季度和年度分析以及中毒频率的比较。检查了来自波兰下西里西亚地区的患者人群。

结果

住院患者人数有所增加，自杀未遂是导致死亡的主要原因。男性中毒和死亡率较高。药物是中毒最常见的原因，其中最常见的是镇静剂和精神药物。在观察期间，由于 NSAIDs，尤其是 OTC 药物引起的中毒明显增加。2005 年，没有报告因 NSAID 中毒导致的死亡病例，而 2015 年死亡率显着增加到 43%。