内皮细胞生长因子和离子载体A23187对猪主动脉内皮细胞中肌醇磷酸生成的刺激作用。
Endothelial cell growth factor and ionophore A23187 stimulation of production of inositol phosphates in porcine aorta endothelial cells.
作者信息
Moscat J, Moreno F, Herrero C, López C, García-Barreno P
机构信息
Medicina Experimental, Hospital General Gregorio Marañon, Madrid, Spain.
出版信息
Proc Natl Acad Sci U S A. 1988 Feb;85(3):659-63. doi: 10.1073/pnas.85.3.659.
Abstract
The existence of a bovine brain-derived endothelial cell growth factor has recently been reported, but its mode of action is unknown. We show that the endothelial cell growth factor is a potent stimulant of inositol monophosphate release in porcine aorta endothelial cells. Although the activation of phospholipase C by this factor does not appear to be dependent on Ca2+, the Ca2+ ionophore A23187 stimulates release of inositol phosphates. It is suggested that the inositol 1,4,5-trisphosphate 3-kinase/5-phosphomonoesterase pathway could account for the ionophore-induced changes in inositol 1,3,4-triphosphate.
摘要
最近有报道称存在一种源自牛脑的内皮细胞生长因子，但其作用方式尚不清楚。我们发现，该内皮细胞生长因子是猪主动脉内皮细胞中肌醇单磷酸释放的强效刺激物。尽管该因子对磷脂酶C的激活似乎不依赖于Ca2+，但Ca2+离子载体A23187可刺激肌醇磷酸的释放。有人提出，肌醇1,4,5-三磷酸3-激酶/5-磷酸单酯酶途径可能是离子载体诱导的肌醇1,3,4-三磷酸变化的原因。
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