“西班牙流感”病毒的基质片段源于禽源性和人流感 A 病毒之间的基因内重配。
The matrix segment of the "Spanish flu" virus originated from intragenic recombination between avian and human influenza A viruses.
机构信息
The Key Laboratory of Animal Resistant Biology of Shandong, College of Life Science, Shandong Normal University, Jinan, China.
出版信息
Transbound Emerg Dis. 2019 Sep;66(5):2188-2195. doi: 10.1111/tbed.13282. Epub 2019 Jul 15.
Abstract
The 1918 Spanish flu virus has claimed more than 50 million lives. However, the mechanism of its high pathogenicity remains elusive; and the origin of the virus is controversial. The matrix (M) segment regulates the replication of influenza A virus, thereby affecting its virulence and pathogenicity. This study found that the M segment of the Spanish flu virus is a recombinant chimera originating from avian influenza virus and human influenza virus. The unique mosaic M segment might confer the virus high replication capacity, showing that the recombination might play an important role in inducing high pathogenicity of the virus. In addition, this study also suggested that the NA and NS segments of the virus were generated by reassortment between mammalian and avian viruses. Direct phylogenetic evidence was also provided for its avian origin.
摘要
1918 年西班牙流感病毒已夺走超过 5000 万人的生命。然而，其高致病性的机制仍难以捉摸；并且病毒的起源存在争议。基质（M）片段调节甲型流感病毒的复制，从而影响其毒力和致病性。本研究发现，西班牙流感病毒的 M 片段是一种源自禽流感病毒和人流感病毒的重组嵌合体。独特的嵌合 M 片段可能赋予病毒高复制能力，表明重组可能在诱导病毒高致病性方面发挥重要作用。此外，本研究还表明，病毒的 NA 和 NS 片段是由哺乳动物和禽流感病毒之间的重配产生的。还为其禽流感起源提供了直接的系统发育证据。
相似文献
1
The matrix segment of the "Spanish flu" virus originated from intragenic recombination between avian and human influenza A viruses.“西班牙流感”病毒的基质片段源于禽源性和人流感 A 病毒之间的基因内重配。
Transbound Emerg Dis. 2019 Sep;66(5):2188-2195. doi: 10.1111/tbed.13282. Epub 2019 Jul 15.
2
Genetic analysis and biological characteristics of different internal gene origin H5N6 reassortment avian influenza virus in China in 2016.2016 年中国不同内部基因来源的 H5N6 重配禽流感病毒的遗传分析及生物学特性。
Vet Microbiol. 2018 Jun;219:200-211. doi: 10.1016/j.vetmic.2018.04.023. Epub 2018 Apr 18.
3
Analysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice.通过单基因重配分析表明，1918 年流感病毒在小鼠中与低致病性禽流感病毒在功能上是兼容的。
J Virol. 2012 Sep;86(17):9211-20. doi: 10.1128/JVI.00887-12. Epub 2012 Jun 20.
4
Detection of reassortant avian influenza A (H11N9) virus in environmental samples from live poultry markets in China.在中国活禽市场环境样本中检测到重组甲型禽流感病毒（H11N9）
Infect Dis Poverty. 2016 Jun 8;5(1):59. doi: 10.1186/s40249-016-0149-2.
5
High frequency of reassortment after co-infection of chickens with the H4N6 and H9N2 influenza A viruses and the biological characteristics of the reassortants.禽流感病毒 H4N6 和 H9N2 感染鸡后频繁发生重配及其重组病毒的生物学特性。
Vet Microbiol. 2018 Aug;222:11-17. doi: 10.1016/j.vetmic.2018.06.011. Epub 2018 Jun 18.
6
Origins and Evolutionary Dynamics of H3N2 Canine Influenza Virus.H3N2犬流感病毒的起源与进化动力学
J Virol. 2015 May;89(10):5406-18. doi: 10.1128/JVI.03395-14. Epub 2015 Mar 4.
7
Highly Pathogenic Avian Influenza Viruses and Generation of Novel Reassortants, United States, 2014-2015.2014 - 2015年美国高致病性禽流感病毒与新型重配病毒的产生
Emerg Infect Dis. 2016 Jul;22(7):1283-5. doi: 10.3201/eid2207.160048.
8
Isolation and genetic characterization of novel reassortant H6N6 subtype avian influenza viruses isolated from chickens in eastern China.从中国东部鸡群中分离出的新型重配H6N6亚型禽流感病毒的分离与基因特征分析
Arch Virol. 2016 Jul;161(7):1859-72. doi: 10.1007/s00705-016-2861-4. Epub 2016 Apr 21.
9
Genetics, pathogenicity and transmissibility of novel reassortant H5N6 highly pathogenic avian influenza viruses first isolated from migratory birds in western China.首次从中国西部候鸟中分离出的新型重配H5N6高致病性禽流感病毒的遗传学、致病性和传播性
Emerg Microbes Infect. 2018 Jan 24;7(1):6. doi: 10.1038/s41426-017-0001-1.
10
The avian-origin PB1 gene segment facilitated replication and transmissibility of the H3N2/1968 pandemic influenza virus.禽源PB1基因片段促进了H3N2/1968大流行性流感病毒的复制和传播能力。
J Virol. 2015 Apr;89(8):4170-9. doi: 10.1128/JVI.03194-14. Epub 2015 Jan 28.
引用本文的文献
1
An ancient influenza genome from Switzerland allows deeper insights into host adaptation during the 1918 flu pandemic in Europe.一份来自瑞士的古代流感病毒基因组，有助于更深入地了解1918年欧洲流感大流行期间病毒对宿主的适应性。
BMC Biol. 2025 Jul 1;23(1):179. doi: 10.1186/s12915-025-02282-z.
2
Intrasegmental recombination as an evolutionary force of Lassa fever virus.节段内重组作为拉沙热病毒的一种进化驱动力。
Front Microbiol. 2024 May 20;15:1411537. doi: 10.3389/fmicb.2024.1411537. eCollection 2024.
3
Isolation and molecular characteristics of a recombinant feline calicivirus from Qingdao, China.中国青岛一株重组猫杯状病毒的分离及分子特征
Vet Res Forum. 2023;14(11):583-588. doi: 10.30466/vrf.2023.1975795.3701. Epub 2023 Nov 15.
4
Immunopathogenesis of Different Emerging Viral Infections: Evasion, Fatal Mechanism, and Prevention.不同新兴病毒感染的免疫发病机制：逃逸、致命机制和预防。
Front Immunol. 2021 Jul 15;12:690976. doi: 10.3389/fimmu.2021.690976. eCollection 2021.
本文引用的文献
1
Zoonotic diseases from birds to humans in Vietnam: possible diseases and their associated risk factors.越南的人兽共患病：从鸟类到人类的潜在疾病及其相关危险因素。
Eur J Clin Microbiol Infect Dis. 2019 Jun;38(6):1047-1058. doi: 10.1007/s10096-019-03505-2. Epub 2019 Feb 26.
2
Spanish influenza redux: revisiting the mother of all pandemics.西班牙流感再现：重温所有大流行之母。
Lancet. 2018 Jun 23;391(10139):2492-2495. doi: 10.1016/S0140-6736(18)31360-6.
3
Emergence and Adaptation of a Novel Highly Pathogenic H7N9 Influenza Virus in Birds and Humans from a 2013 Human-Infecting Low-Pathogenic Ancestor.一种新型高致病性H7N9流感病毒从2013年感染人类的低致病性祖先毒株在鸟类和人类中出现及适应性演变。
J Virol. 2018 Jan 2;92(2). doi: 10.1128/JVI.00921-17. Print 2018 Jan 15.
4
A permanent host shift of rabies virus from Chiroptera to Carnivora associated with recombination.狂犬病病毒从翼手目到食肉目永久宿主转移与重组有关。
Sci Rep. 2017 Mar 21;7(1):289. doi: 10.1038/s41598-017-00395-2.
5
New genetic mechanism, origin and population dynamic of bovine ephemeral fever virus.牛流行热病毒的新遗传机制、起源及群体动态
Vet Microbiol. 2016;182:50-6. doi: 10.1016/j.vetmic.2015.10.029. Epub 2015 Oct 31.
6
Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia.沙特阿拉伯三种骆驼冠状病毒的共同循环和 MERS-CoV 的重组。
Science. 2016 Jan 1;351(6268):81-4. doi: 10.1126/science.aac8608. Epub 2015 Dec 17.
7
H7N9 influenza viruses are transmissible in ferrets by respiratory droplet.H7N9 流感病毒可通过飞沫在雪貂间传播。
Science. 2013 Jul 26;341(6144):410-4. doi: 10.1126/science.1240532. Epub 2013 Jul 18.
8
Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice.雪貂和小鼠中甲型流感病毒（H7N9）的发病机制和传播。
Nature. 2013 Sep 26;501(7468):556-9. doi: 10.1038/nature12391. Epub 2013 Jul 10.
9
Characterization of H7N9 influenza A viruses isolated from humans.人感染 H7N9 流感病毒的特征。
Nature. 2013 Sep 26;501(7468):551-5. doi: 10.1038/nature12392. Epub 2013 Jul 10.
10
Discovery of severe fever with thrombocytopenia syndrome bunyavirus strains originating from intragenic recombination.发现源自基因内重组的严重发热伴血小板减少综合征布尼亚病毒株。
J Virol. 2012 Nov;86(22):12426-30. doi: 10.1128/JVI.01317-12. Epub 2012 Aug 29.
Zotero 插件