“西班牙流感”病毒的基质片段源于禽源性和人流感 A 病毒之间的基因内重配。
The matrix segment of the "Spanish flu" virus originated from intragenic recombination between avian and human influenza A viruses.
机构信息
The Key Laboratory of Animal Resistant Biology of Shandong, College of Life Science, Shandong Normal University, Jinan, China.
出版信息
Transbound Emerg Dis. 2019 Sep;66(5):2188-2195. doi: 10.1111/tbed.13282. Epub 2019 Jul 15.
The 1918 Spanish flu virus has claimed more than 50 million lives. However, the mechanism of its high pathogenicity remains elusive; and the origin of the virus is controversial. The matrix (M) segment regulates the replication of influenza A virus, thereby affecting its virulence and pathogenicity. This study found that the M segment of the Spanish flu virus is a recombinant chimera originating from avian influenza virus and human influenza virus. The unique mosaic M segment might confer the virus high replication capacity, showing that the recombination might play an important role in inducing high pathogenicity of the virus. In addition, this study also suggested that the NA and NS segments of the virus were generated by reassortment between mammalian and avian viruses. Direct phylogenetic evidence was also provided for its avian origin.
1918 年西班牙流感病毒已夺走超过 5000 万人的生命。然而，其高致病性的机制仍难以捉摸；并且病毒的起源存在争议。基质（M）片段调节甲型流感病毒的复制，从而影响其毒力和致病性。本研究发现，西班牙流感病毒的 M 片段是一种源自禽流感病毒和人流感病毒的重组嵌合体。独特的嵌合 M 片段可能赋予病毒高复制能力，表明重组可能在诱导病毒高致病性方面发挥重要作用。此外，本研究还表明，病毒的 NA 和 NS 片段是由哺乳动物和禽流感病毒之间的重配产生的。还为其禽流感起源提供了直接的系统发育证据。
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