Willner P, Towell A, Sampson D, Sophokleous S, Muscat R
Psychology Department, City of London Polytechnic, UK.
Psychopharmacology (Berl). 1987;93(3):358-64. doi: 10.1007/BF00187257.
Rats exposed chronically (5-9 weeks) to a variety of mild unpredictable stressors showed a reduced consumption of and preference for saccharin or sucrose solutions. Preference deficits took at least 2 weeks to develop and were maintained for more than 2 weeks after termination of the stress regime. Sucrose preference was unaffected by 1 week of treatment with the tricyclic antidepressant DMI but returned to normal after 2-4 weeks of DMI treatment. DMI did not alter sucrose preference in unstressed animals. No significant changes were seen in saline preference either during stress or following drug treatment. DMI reduced blood corticosterone and glucose levels, but stress did not significantly alter either measure. The results are discussed in terms of an animal model of endogenous depression.
长期（5 - 9周）暴露于各种轻度不可预测应激源的大鼠，对糖精或蔗糖溶液的消耗量和偏好降低。偏好缺陷至少需要2周时间才会出现，并在应激方案终止后持续2周以上。三环类抗抑郁药去甲丙咪嗪（DMI）治疗1周对蔗糖偏好没有影响，但在DMI治疗2 - 4周后恢复正常。DMI对未受应激动物的蔗糖偏好没有改变。在应激期间或药物治疗后，盐水偏好均未出现显著变化。DMI降低了血液皮质酮和葡萄糖水平，但应激对这两项指标均无显著影响。本文根据内源性抑郁症的动物模型对结果进行了讨论。
