Kokkinidis L, Zacharko R M, Predy P A
Pharmacol Biochem Behav. 1980 Sep;13(3):379-83. doi: 10.1016/0091-3057(80)90242-7.
The effects of long-term amphetamine treatment were examined on self-stimulation responding from the substantia nigra. Rates of self-stimulation responding were substantially depressed among rats chronically treated with amphetamine and tested in the absence of the drug. When rats were subsequently retested after a two day hiatus in which they received imipramine or amitriptyline, the post-amphetamine depression of rates of self-stimulation responding was mitigated. The efficacy of imipramine and amitriptyline in reversing the post-amphetamine depression of self-stimulation responding was also evident during a continuation of the drug (imipramine or amitriptyline)/test sequence, for seven test sessions. The results of the present investigation were related to changes in dopamine and acetylcholine neurotransmission following long-term amphetamine treatement.
研究了长期使用苯丙胺治疗对黑质自刺激反应的影响。在长期接受苯丙胺治疗且在无药物情况下进行测试的大鼠中，自刺激反应率大幅降低。当大鼠在停药两天后接受丙咪嗪或阿米替林治疗，随后再次进行测试时，苯丙胺治疗后自刺激反应率的降低得到缓解。在药物（丙咪嗪或阿米替林）/测试序列持续进行的七个测试阶段中，丙咪嗪和阿米替林逆转苯丙胺治疗后自刺激反应降低的效果也很明显。本研究结果与长期使用苯丙胺治疗后多巴胺和乙酰胆碱神经传递的变化有关。
