From the Department of Nuclear Medicine, Bichat University Hospital, Assistance Publique-Hôpitaux de Paris (F.H.), University Paris 7 René Diderot, France.
INSERM U1148, Laboratory for Vascular Translational Science, DHU FIRE (F.H., J.V.), University Paris 7 René Diderot, France.
Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1369-1378. doi: 10.1161/ATVBAHA.119.312586. Epub 2019 May 23.
Noninvasive imaging technologies offer to identify several anatomic and molecular features of high-risk plaques. For the noninvasive molecular imaging of atherosclerotic plaques, nuclear medicine constitutes one of the best imaging modalities, thanks to its high sensitivity for the detection of probes in tissues. 18F-fluorodeoxyglucose (FDG) is currently the most widely used radiopharmaceutical for molecular imaging of atherosclerotic plaques with positron emission tomography. The intensity of FDG uptake in the vascular wall correlates closely with the degree of macrophage infiltration in atherosclerotic plaques. FDG positron emission tomographic imaging has become a powerful tool to identify and monitor noninvasively inflammatory activities in atherosclerotic plaques over time. This review examines how FDG positron emission tomographic imaging has given us deeper insight into the role of inflammation in atherosclerotic plaque progression and discusses perspectives for alternative radiopharmaceuticals to FDG that could provide a more specific and simple identification of high-risk lesions and help improve risk stratification of atherosclerotic patients. Visual Overview- An online visual overview is available for this article.
非侵入性成像技术可用于识别高危斑块的多种解剖和分子特征。对于动脉粥样硬化斑块的非侵入性分子成像，核医学是最好的成像方式之一，这要归功于其对组织中探针的高灵敏度检测。18F-氟脱氧葡萄糖（FDG）是目前最广泛用于正电子发射断层扫描（PET）检测动脉粥样硬化斑块的放射性药物。血管壁中 FDG 的摄取强度与动脉粥样硬化斑块中巨噬细胞浸润的程度密切相关。FDG 正电子发射断层扫描成像已成为一种强大的工具，可用于随时间非侵入性地识别和监测动脉粥样硬化斑块中的炎症活动。本文综述了 FDG 正电子发射断层扫描成像如何使我们更深入地了解炎症在动脉粥样硬化斑块进展中的作用，并讨论了替代 FDG 的放射性药物的前景，这些药物可以更准确和简单地识别高危病变，并有助于改善动脉粥样硬化患者的风险分层。
