Medizinische Klinik und Poliklinik I, Klinikum der Ludwig-Maximilians-Universität München, Munich, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
Thromb Haemost. 2019 Aug;119(8):1237-1246. doi: 10.1055/s-0039-1692665. Epub 2019 Jun 26.
Atherosclerosis is a prevalent inflammatory condition and a frequent cause of morbidity and mortality worldwide. Macrophages are among the key immune cells driving lesion formation in the arterial wall. They have therefore evolved as potential targets for therapeutic strategies. Understanding of the different macrophage phenotypes and functions seems to be of pivotal importance for the development of treatments to target these immune cells. This review highlights the complexity of the mononuclear phagocyte system and summarizes important features of macrophage biology contributing to atherosclerosis.
动脉粥样硬化是一种普遍存在的炎症性疾病，也是全球发病率和死亡率的主要原因。巨噬细胞是驱动动脉壁病变形成的关键免疫细胞之一。因此，它们已成为治疗策略的潜在靶点。了解不同的巨噬细胞表型和功能似乎对开发针对这些免疫细胞的治疗方法至关重要。本综述强调了单核吞噬细胞系统的复杂性，并总结了促进动脉粥样硬化发生的巨噬细胞生物学的重要特征。
