Jennings F W
Department of Veterinary Parasitology, University of Glasgow, England.
Trop Med Parasitol. 1991 Jun;42(2):135-8.
The currently available anti-leishmanial antimonial drugs, together with other antimony compounds were individually tested, in combination with difluoromethylornithine (DFMO), against experimental murine trypanosomiasis with central nervous system involvement. Satisfactory cure rates could be achieved using a combination treatment of DFMO with most of these anti-leishmanial drugs, but in general, only when they were administered at least twice daily. Of the compounds tested, the most effective was antimony dimercaptosuccinate (Astiban).
对目前可用的抗利什曼原虫的锑剂药物以及其他锑化合物，分别与二氟甲基鸟氨酸（DFMO）联合，针对伴有中枢神经系统受累的实验性鼠锥虫病进行了测试。使用DFMO与这些抗利什曼原虫药物中的大多数联合治疗可取得满意的治愈率，但一般来说，只有在每天至少给药两次时才行。在所测试的化合物中，最有效的是二巯基琥珀酸锑（司替班）。
