Bioregenerative Medicine and Applied Surgery Research Group, Department of Animal Medicine and Surgery, CEU Cardenal Herrera University, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain.
García Cugat Foundation CEU-UCH Chair of Medicine and Regenerative Surgery, CEU Cardenal Herrera University, CEU Universities, C/Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain.
Int J Mol Sci. 2019 Jun 25;20(12):3105. doi: 10.3390/ijms20123105.
Chronic musculoskeletal (MSK) pain is one of the most common medical complaints worldwide and musculoskeletal injuries have an enormous social and economical impact. Current pharmacological and surgical treatments aim to relief pain and restore function; however, unsatiscactory outcomes are commonly reported. In order to find an accurate treatment to such pathologies, over the last years, there has been a significantly increasing interest in cellular therapies, such as adipose-derived mesenchymal stem cells (AMSCs). These cells represent a relatively new strategy in regenerative medicine, with many potential applications, especially regarding MSK disorders, and preclinical and clinical studies have demonstrated their efficacy in muscle, tendon, bone and cartilage regeneration. Nevertheless, several worries about their safety and side effects at long-term remain unsolved. This article aims to review the current state of AMSCs therapy in the treatment of several MSK diseases and their clinical applications in veterinary and human medicine.
慢性肌肉骨骼（MSK）疼痛是全球最常见的医学主诉之一，肌肉骨骼损伤具有巨大的社会和经济影响。目前的药物和手术治疗旨在缓解疼痛和恢复功能；然而，通常报告的结果并不令人满意。为了找到针对此类病变的准确治疗方法，近年来，人们对细胞疗法（如脂肪来源的间充质干细胞（AMSCs））产生了极大的兴趣。这些细胞代表了再生医学中一种相对较新的策略，具有许多潜在的应用，特别是在肌肉骨骼疾病方面，临床前和临床研究已经证明了它们在肌肉、肌腱、骨骼和软骨再生方面的疗效。然而，关于其长期安全性和副作用的一些担忧仍然没有得到解决。本文旨在综述 AMSCs 疗法在几种 MSK 疾病治疗中的现状及其在兽医和人类医学中的临床应用。
