Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, People's Republic of China.
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
Nat Prod Res. 2020 Nov;34(21):3117-3124. doi: 10.1080/14786419.2019.1610758. Epub 2019 Jun 26.
Two new chromones, spororrminone A (, ()-5-hydroxy-2-methyl-4-oxo-2-(()-5-oxotetrahydrofuran-2-yl)chroman-7-carboxylic acid) and 2--spororrminone A (, ()-5-hydroxy-2-methyl-4-oxo-2-(()-5-oxotetrahydrofuran-2-yl)chroman-7-carboxylic acid), were isolated from an EtOAc extract of an endolichenic fungal strain (No. 71-11-4-1). The structures of these compounds were identified by spectroscopic analyses. The absolute configuration of was established by single-crystal X-ray diffraction. Spororrminone A () and 2--spororrminone A () represent the first examples of 2-(5-oxotetrahydrofuran-2-yl) chromones with 7-carboxylic group.
从内生真菌菌株 (No. 71-11-4-1) 的 EtOAc 提取物中分离得到两个新的色酮化合物，spororrminone A (, ()-5-hydroxy-2-methyl-4-oxo-2-(()-5-oxotetrahydrofuran-2-yl)chroman-7-carboxylic acid) 和 2--spororrminone A (, ()-5-hydroxy-2-methyl-4-oxo-2-(()-5-oxotetrahydrofuran-2-yl)chroman-7-carboxylic acid)。这些化合物的结构通过光谱分析确定。通过单晶 X 射线衍射确定了 的绝对构型。Spororrminone A () 和 2--spororrminone A () 代表具有 7-羧酸基团的 2-(5-氧代四氢呋喃-2-基)色酮的首例。
