School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, People's Republic of China.
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, People's Republic of China.
Phytochemistry. 2024 May;221:114046. doi: 10.1016/j.phytochem.2024.114046. Epub 2024 Mar 7.
Eight previously undescribed chromones eleusineketones A-H (1-8), as well as eight known compounds (9-16), were isolated from the endophytic fungus Bipolaris eleusines. These planar structures were created using an in-depth analysis of their spectral data, which included 1D, 2D, and HRESIMS data. Furthermore, the absolute configurations of compounds 1, 2, and 6 were determined by spectroscopic analysis and quantum chemical computational approaches, and compound 5 was determined by single-crystal X-ray diffraction analysis. The cytotoxic activity assay revealed that compounds 1 and 5 both inhibited MDA-MB-231 cells with IC values of 14.48 μM and 17.99 μM, respectively.
从内生真菌禾谷镰刀菌中分离得到了 8 个以前未描述的色酮类化合物（1-8），以及 8 个已知化合物（9-16）。这些平面结构是通过对其光谱数据进行深入分析得到的，包括 1D、2D 和 HRESIMS 数据。此外，通过光谱分析和量子化学计算方法确定了化合物 1、2 和 6 的绝对构型，通过单晶 X 射线衍射分析确定了化合物 5 的绝对构型。细胞毒性活性测定表明，化合物 1 和 5 对 MDA-MB-231 细胞均具有抑制活性，IC 值分别为 14.48 μM 和 17.99 μM。
