高血压患者脑白质高信号的体积随血压升高而增加。
Volume of white matter hyperintensities increases with blood pressure in patients with hypertension.
作者信息
Zhao Yu, Ke Zunyu, He Wenbo, Cai Zhiyou
机构信息
1 Department of Neurology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
2 Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan Renmin Hospital, Shiyan, Hubei Province, China.
出版信息
J Int Med Res. 2019 Aug;47(8):3681-3689. doi: 10.1177/0300060519858023. Epub 2019 Jun 26.
OBJECTIVE
Hypertension is a risk factor for development of white matter hyperintensities (WMHs). However, the relationship between hypertension and WMHs remains obscure. We sought to clarify this relationship using clinical data from different regions of China.
METHODS
We analyzed the data of 333 patients with WMHs in this study. All included patients underwent conventional magnetic resonance imaging (MRI) examination. A primary diagnosis of WMHs was made according to MRI findings. The volume burden of WMHs was investigated using the Fazekas scale, which is widely used to rate the degree of WMHs. We conducted retrospective clinical analysis of the data in this study.
RESULTS
Our findings showed that WMHs in patients with hypertension were associated with diabetes, cardiovascular diseases, history of cerebral infarct, and plasma glucose and triglyceride levels. Fazekas scale scores for WMHs increased with increased blood pressure values in patients with hypertension.
CONCLUSION
This analysis indicates that hypertension is an independent contributor to the prevalence and severity of WMHs.
目的
高血压是白质高信号（WMHs）发生的一个危险因素。然而，高血压与WMHs之间的关系仍不明确。我们试图利用来自中国不同地区的临床数据来阐明这种关系。
方法
在本研究中，我们分析了333例WMHs患者的数据。所有纳入患者均接受了常规磁共振成像（MRI）检查。根据MRI结果做出WMHs的初步诊断。使用广泛用于评估WMHs程度的 Fazekas量表来研究WMHs的体积负荷。我们对本研究中的数据进行了回顾性临床分析。
结果
我们的研究结果表明，高血压患者的WMHs与糖尿病、心血管疾病、脑梗死病史以及血糖和甘油三酯水平相关。高血压患者中，WMHs的Fazekas量表评分随血压值升高而增加。
结论
该分析表明，高血压是WMHs患病率和严重程度的一个独立影响因素。
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