Liu Yong, Sun Xingxing, Qian Wei, Liu Wantao, Mei Wei
Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Reg Anesth Pain Med. 2019 Jun 25. doi: 10.1136/rapm-2019-100570.
Our previous work found that needle visibility could be improved by introducing microbubbles into needles. The primary aim of this study was to test the hypothesis that the negative pressure method is superior to two other methods for enhancing needle visibility by introducing microbubbles into needles. The secondary aim was to evaluate the impacts of three factors on the visibility of microbubble-filled needles.
In the first phase, three methods, including the negative pressure method, the mixing method and commercialized microbubbles, were applied to generate microbubbles inside needles for comparison of visibility in a porcine meat model. In the second phase, three factors were tested with a 2×5×5 factorial design to explore their influence on the visibility of microbubble-filled needles. The three factors included types of needles, insertion angles and types of contents inside needles. Needles filled with saline without microbubbles were used as the control in both phases. Insertion videos were recorded, and ultrasound images of needles were captured for the objective visibility analysis.
Needle visibility was highest in the negative pressure method group (p<0.001). Needle visibility was mainly determined by insertion angles (p<0.001). Microbubble-filled needles were more visible than control needles at 40°, 50° and 60° (p<0.001, p<0.001 and p<0.001, respectively).
Needle visibility can be significantly improved by microbubbles generated with the negative pressure method when insertion angles are 40°, 50° and 60° in porcine meat.
我们之前的研究发现，向针内引入微泡可提高针的可视性。本研究的主要目的是验证负压法在通过向针内引入微泡来增强针的可视性方面优于其他两种方法这一假设。次要目的是评估三个因素对充满微泡的针的可视性的影响。
在第一阶段，应用三种方法，包括负压法、混合法和商业化微泡，在针内产生微泡，以比较在猪肉模型中的可视性。在第二阶段，采用2×5×5析因设计测试三个因素，以探讨它们对充满微泡的针的可视性的影响。这三个因素包括针的类型、插入角度和针内的内容物类型。在两个阶段中，均使用未含微泡的生理盐水填充的针作为对照。记录插入过程的视频，并采集针的超声图像以进行客观的可视性分析。
负压法组的针可视性最高（p<0.001）。针的可视性主要由插入角度决定（p<0.001）。在40°、50°和60°时，充满微泡的针比对照针更易见（分别为p<0.001、p<0.001和p<0.001）。
在猪肉中，当插入角度为40°、50°和60°时，通过负压法产生的微泡可显著提高针的可视性。
