Ivanov A N, Saveleva M S, Kurtukova M O, Kustodov S V, Gladkova E V, Blinnikova V V, Babushkina I V, Parakhonskiy B V, Ulyanov V Yu, Norkin I A
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation, Saratov, Russia.
Bull Exp Biol Med. 2019 Jun;167(2):275-278. doi: 10.1007/s10517-019-04508-x. Epub 2019 Jun 26.
We studied the particularities of osteo- and angiogenesis in albino rats after implantation of polycaprolactone scaffolds mineralized with vaterite with adsorbed tannic acid in the femoral bone defect. It was found that the processes of angio- and osteogenesis in the bone tissue after scaffolds implantation depend on their biocompatibility. Implantation of non-biocompatible scaffolds was followed by activation of angio- and osteogenesis aimed at separation of these scaffold from surrounding tissues. Implantation of polycaprolactone/vaterite scaffolds containing tannic acid stimulated angio- and osteogenesis leading to vascularization and bone tissue formation in the matrix. This demonstrate prospects of clinical approbation of these scaffolds for stimulation of bone regeneration in traumatological and orthopedic patients.
我们研究了在股骨骨缺损处植入吸附了单宁酸的球霰石矿化聚己内酯支架后，白化大鼠骨生成和血管生成的特性。研究发现，支架植入后骨组织中的血管生成和骨生成过程取决于它们的生物相容性。植入非生物相容性支架后，会激活血管生成和骨生成，目的是将这些支架与周围组织分离。植入含单宁酸的聚己内酯/球霰石支架可刺激血管生成和骨生成，导致基质中血管化和骨组织形成。这证明了这些支架在创伤学和矫形患者中促进骨再生的临床应用前景。
