Saveleva Mariia, Prikhozhdenko Ekaterina, Gorin Dmitry, Skirtach Andre G, Yashchenok Alexey, Parakhonskiy Bogdan
Department of Biotechnology, Ghent University, Ghent, Belgium.
Education and Research Institute of Nanostructures and Biosystems, Saratov State University, Saratov, Russia.
Front Chem. 2020 Jan 10;7:888. doi: 10.3389/fchem.2019.00888. eCollection 2019.
Surface-enhanced Raman scattering (SERS) is a high-performance technique allowing detection of extremely low concentrations of analytes. For such applications, fibrous polymeric matrices decorated with plasmonic metal nanostructures can be used as flexible SERS substrates for analysis of analytes in many application. In this study, a three-dimensional SERS substrate consisting of a CaCO-mineralized electrospun (ES) polycaprolactone (PCL) fibrous matrix decorated with silver (Ag) nanoparticles is developed. Such modification of the fibrous substrate allows achieving a significant increase of the SERS signal amplification. Functionalization of fibers by porous CaCO (vaterite) and Ag nanoparticles provides an effective approach of selective adsorption of biomolecules and their precise detection by SERS. This new SERS substrate represents a promising biosensor platform with selectivity to low and high molecular weight molecules.
表面增强拉曼散射（SERS）是一种高性能技术，可用于检测极低浓度的分析物。对于此类应用，装饰有等离子体金属纳米结构的纤维聚合物基质可作为灵活的SERS底物，用于多种应用中的分析物分析。在本研究中，开发了一种三维SERS底物，它由用银（Ag）纳米颗粒装饰的碳酸钙矿化电纺（ES）聚己内酯（PCL）纤维基质组成。纤维底物的这种修饰可实现SERS信号放大的显著增加。多孔碳酸钙（球霰石）和银纳米颗粒对纤维的功能化提供了一种选择性吸附生物分子并通过SERS对其进行精确检测的有效方法。这种新型SERS底物代表了一种对低分子量和高分子量分子具有选择性的有前途的生物传感器平台。
