Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
Mol Oncol. 2019 Aug;13(8):1623-1650. doi: 10.1002/1878-0261.12537. Epub 2019 Jul 30.
Reliable biomarkers are required to evaluate and manage pancreatic ductal adenocarcinoma. Circulating tumor cells and circulating tumor DNA are shed into blood and can be relatively easily obtained from minimally invasive liquid biopsies for serial assays and characterization, thereby providing a unique potential for early diagnosis, forecasting disease prognosis, and monitoring of therapeutic response. In this review, we provide an overview of current technologies used to detect circulating tumor cells and circulating tumor DNA and describe recent advances regarding the multiple clinical applications of liquid biopsy in pancreatic ductal adenocarcinoma.
需要可靠的生物标志物来评估和管理胰腺导管腺癌。循环肿瘤细胞和循环肿瘤 DNA 会脱落到血液中，并且可以从微创的液体活检中相对容易地获得，用于连续检测和特征分析，从而为早期诊断、预测疾病预后和监测治疗反应提供了独特的潜力。在这篇综述中，我们概述了目前用于检测循环肿瘤细胞和循环肿瘤 DNA 的技术，并描述了液体活检在胰腺导管腺癌的多个临床应用中的最新进展。
