灵芝属真菌子实体中具有 BACE1 抑制活性的倍半萜类化合物
Meroterpenoids with BACE1 Inhibitory Activity from the Fruiting Body of .
机构信息
Department of Pharmacognosy and Phytochemistry , Meiji Pharmaceutical University , Noshio 2-522-1 , Kiyose-shi , Tokyo 204-8588 , Japan.
Department of Bioinformatics and Molecular Neuropathology , Meiji Pharmaceutical University , 2-522-1, Noshio , Kiyose-shi , Tokyo 204-8588 , Japan.
出版信息
J Nat Prod. 2019 Jul 26;82(7):1797-1801. doi: 10.1021/acs.jnatprod.8b01092. Epub 2019 Jun 25.
BACE1 inhibitory activity-guided fractionation of an extract of the fruiting body of yielded five novel meroterpenoids (-) and one known compound (; asiaticusin A). The structures of these compounds were determined by interpretation of NMR, MS, and IR spectral data. The five new compounds contain 4-hydroxybenzoic acid and geranylgeranoic acid units. Compounds - possessed BACE1 inhibitory activity (IC values: 14.7, 11.4, and 2.0 μM, respectively).
从真菌担子果中提取的化合物经 BACE1 抑制活性导向分离，得到五个新的倍半萜烯类化合物（-）和一个已知化合物（; asiaticusin A）。这些化合物的结构通过 NMR、MS 和 IR 光谱数据的解析来确定。这五个新化合物含有 4-羟基苯甲酸和香叶基香叶基酸单元。化合物 - 具有 BACE1 抑制活性（IC 值分别为 14.7、11.4 和 2.0 μM）。
Zotero 插件