五种具有细胞毒性的担子菌子实体中的新倍半萜。
Five New Meroterpenoids from the Fruiting Bodies of the Basidiomycete with Cytotoxic Activity.
机构信息
Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
Department of Biomedicine, Beijing City University, Beijing 100094, China.
出版信息
Molecules. 2019 Nov 6;24(22):4015. doi: 10.3390/molecules24224015.
Five new meroterpenoids, clavipols A-B (-) with a 12-membered ether ring and clavilactones G-I (-) having a 10-membered carbocycle connected to a hydroquinone and an α,β-epoxy/unsaturated lactone, were obtained from the fruiting bodies of the basidiomycete . Their structures were determined by comprehensive analysis of their spectroscopic data, and the absolute configuration of was established by quantum chemical calculations of electronic circular dichroism (ECD). All the isolated compounds (-) were tested for their cytotoxic activity against three human tumor cell lines (Hela, SGC-7901, and SHG-44) in vitro after treatment for 48 h. Compound exhibited moderate cytotoxic activity against Hela and SGC-7901 tumor cell lines, with IC values of 23.5 and 14.5 µM, respectively.
五种新的倍半萜类化合物，clavipols A-B（-）具有 12 元醚环，clavilactones G-I（-）具有连接到对苯二酚和α，β-环氧/不饱和内酯的 10 元碳环，从担子菌类的子实体中获得。通过对其光谱数据的综合分析确定了它们的结构，并通过量子化学计算电子圆二色性（ECD）确定了的绝对构型。所有分离得到的化合物（-）在体外处理 48 小时后均针对三种人肿瘤细胞系（Hela、SGC-7901 和 SHG-44）进行了细胞毒性活性测试。化合物对 Hela 和 SGC-7901 肿瘤细胞系表现出中等的细胞毒性活性，IC 值分别为 23.5 和 14.5 μM。
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