Natural Product Research Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
College of Korean Medicine, Gachon University, Seongnam, 13120, Republic of Korea.
J Antibiot (Tokyo). 2020 Oct;73(10):729-732. doi: 10.1038/s41429-020-0328-z. Epub 2020 May 29.
Phallus luteus (Phallaceae), previously known as Dictyophora indusiata, is an edible and medicinal mushroom. As part of a continuing project to discover structurally and/or biologically novel natural products from wild mushrooms, we aimed to perform a chemical investigation of the methanol extract of P. luteus combined with a liquid chromatography-mass spectrometry-guided analysis coupled to an in-house UV spectral library. Two new sesquiterpenes, phallac acids A (1) and B (2), were isolated and determined. The chemical structure of the new natural products was unambiguously determined using a combination of 1D and 2D NMR and high-resolution electrospray ionization mass spectrometry data. To our knowledge, this is the first study to report linear sesquiterpene carboxylic acids from P. luteus. The new compounds were evaluated for α-glucosidase inhibitory activities where phallac acid B (2) showed α-glucosidase inhibitory potential (IC value of 94.89 ± 5.57 μM) compared with the standard acarbose (IC value of 26.23 ± 1.31 μM).
黄蓝柄牛肝菌（牛肝菌科），以前被称为网孢牛肝菌，是一种可食用和药用蘑菇。作为一项正在进行的从野生蘑菇中发现具有结构和/或生物新颖性的天然产物的项目的一部分，我们旨在对黄蓝柄牛肝菌的甲醇提取物进行化学研究，该提取物与液质联用分析相结合，并附有内部 UV 光谱库。分离并确定了两种新的倍半萜酸，黄蓝柄牛肝菌素 A（1）和 B（2）。使用一维和二维 NMR 以及高分辨率电喷雾电离质谱数据的组合，明确确定了新天然产物的化学结构。据我们所知，这是首次报道来自黄蓝柄牛肝菌的线性倍半萜酸。评估了新化合物对α-葡萄糖苷酶抑制活性的影响，其中黄蓝柄牛肝菌素 B（2）显示出α-葡萄糖苷酶抑制潜力（IC 值为 94.89 ± 5.57 μM），而标准阿卡波糖（IC 值为 26.23 ± 1.31 μM）。
