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电针通过调节高脂饮食诱导的肥胖小鼠脂肪组织中与脂肪褐变相关的蛋白质来减轻体重。

Electroacupuncture Reduces Body Weight by Regulating Fat Browning-Related Proteins of Adipose Tissue in HFD-Induced Obese Mice.

作者信息

Lu Sheng-Feng, Tang Yue-Xia, Zhang Tao, Fu Shu-Ping, Hong Hao, Cheng Yu, Xu Hou-Xi, Jing Xing-Yue, Yu Mei-Ling, Zhu Bing-Mei

机构信息

Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing, China.

Huai'an Hospital of Traditional Chinese Medicine, Huaian, China.

出版信息

Front Psychiatry. 2019 Jun 11;10:353. doi: 10.3389/fpsyt.2019.00353. eCollection 2019.

DOI:10.3389/fpsyt.2019.00353
PMID:31244685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6580183/
Abstract

This study investigated the influence of electroacupuncture (EA) and its potential underlying mechanisms on adipose tissue in obese mice. Three-week-old male C56BL/6 mice were randomly divided to feed or not to feed high-fat diet (HFD), named HFD group and chow diet (CD) group, respectively. After 12 weeks, CD and HFD mice were randomly divided into two groups, respectively, to receive or not receive EA for 4 weeks. Body weight (BW) was monitored. Intraperitoneal glucose tolerance test and metabolic chamber recordings were performed. Blood samples and adipose tissue were collected for the analysis of leptin, triglyceride levels, and fat browning-related proteins. EA significantly reduced food intake, BW, and white adipose tissue (WAT)/BW ratio; decreased the adipocyte size and serum concentrations of triglyceride (TG) and cholesterol; and increased oxygen consumption in HFD mice. Compared with the CD mice, the HFD mice had elevated fasting serum glucose level and impaired glucose tolerance; however, these parameters were decreased by EA treatment. Meanwhile, EA promoted the protein and mRNA expressions of UCP1, PRDM16, and PGC-1α in adipose tissue, and activated sympathetic nerves p-TH, A2AR, and β3AR in white adipose tissue. EA reduced food intake, BW, TG, and cholesterol, and improved glucose tolerance in HFD mice. This ameliorative effect of EA on obesity-related symptoms associated with its promoted adipose tissue plasticity activating sympathetic nerves.

摘要

本研究探讨了电针（EA）对肥胖小鼠脂肪组织的影响及其潜在机制。将3周龄雄性C56BL/6小鼠随机分为高脂饮食组（HFD组）和普通饮食组（CD组），分别给予或不给予高脂饮食。12周后，将CD组和HFD组小鼠再分别随机分为两组，一组接受4周的EA治疗，另一组不接受。监测体重（BW）。进行腹腔葡萄糖耐量试验和代谢室记录。采集血样和脂肪组织，分析瘦素、甘油三酯水平及与脂肪褐变相关的蛋白。电针显著降低了HFD小鼠的食物摄入量、体重及白色脂肪组织（WAT）/体重比值；减小了脂肪细胞大小，降低了血清甘油三酯（TG）和胆固醇浓度；增加了耗氧量。与CD组小鼠相比，HFD组小鼠空腹血清葡萄糖水平升高，葡萄糖耐量受损；然而，电针治疗降低了这些参数。同时，电针促进了脂肪组织中解偶联蛋白1（UCP1）、PR结构域蛋白16（PRDM16）和过氧化物酶体增殖物激活受体γ辅激活因子1α（PGC-1α）的蛋白和mRNA表达，并激活了白色脂肪组织中的交感神经p-TH、A2A受体（A2AR）和β3肾上腺素能受体（β3AR）。电针降低了HFD小鼠的食物摄入量、体重、TG和胆固醇水平，并改善了葡萄糖耐量。电针对肥胖相关症状的改善作用与其促进脂肪组织可塑性及激活交感神经有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c42/6580183/dbfca5067b3f/fpsyt-10-00353-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c42/6580183/146df9766ded/fpsyt-10-00353-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c42/6580183/146df9766ded/fpsyt-10-00353-g001.jpg
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Obesity as a Disease: The Obesity Society 2018 Position Statement.肥胖是一种疾病：肥胖学会 2018 立场声明。
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