金属有机框架的纳米医学生物工程。

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States.

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore.

Theranostics. 2019 May 18;9(11):3122-3133. doi: 10.7150/thno.31918. eCollection 2019.

Controlled structure, tunable porosity, and readily chemical functionalizability make metal-organic frameworks (MOFs) a powerful biomedical tool. Nanoscale MOF particles have been increasingly studied as drug carriers, bioimaging agents, and therapeutic agents due to their excellent physiochemical properties. In this review, we start with MOF as a nanocarrier for drug delivery, covering therapeutic MOF agents followed by a comprehensive discussion of surface bioengineering of MOF for improved biostability, biocompatibility, and targeted delivery. Finally, we detail the challenges and prospects of the future of MOF research for biomedical applications.

可控结构、可调孔隙率和易于化学功能化使金属有机骨架（MOF）成为一种强大的生物医学工具。由于其优异的物理化学性质，纳米级 MOF 颗粒已越来越多地被研究作为药物载体、生物成像剂和治疗剂。在本综述中，我们首先介绍了 MOF 作为药物传递的纳米载体，涵盖了治疗性 MOF 剂，然后全面讨论了 MOF 的表面生物工程，以提高生物稳定性、生物相容性和靶向传递。最后，我们详细说明了 MOF 用于生物医学应用的未来研究的挑战和前景。