Department of Pharmaceutical Sciences, College of Pharmacy, Robertson Life Sciences Building, Oregon State University, Portland, OR.
Department of Biomedical Engineering, Robertson Life Sciences Building, Oregon Health Science University, Portland, OR.
Theranostics. 2019 May 18;9(11):3191-3212. doi: 10.7150/thno.33921. eCollection 2019.
Cells utilize natural supramolecular assemblies to maintain homeostasis and biological functions. Naturally inspired modular assembly of biomaterials are now being exploited for understanding or manipulating cell biology for treatment, diagnosis, and detection of diseases. Supramolecular biomaterials, in particular peptides and oligonucleotides, can be precisely tuned to have diverse structural, mechanical, physicochemical and biological properties. These merits of oligonucleotides and peptides as building blocks have given rise to the evolution of numerous nucleic acid- and peptide-based self-assembling nanomaterials for various medical applications, including drug delivery, tissue engineering, regenerative medicine, and immunotherapy. In this review, we provide an extensive overview of the intracellular delivery approaches using supramolecular self-assembly of DNA, RNA, and peptides. Furthermore, we discuss the current challenges related to subcellular delivery and provide future perspectives of the application of supramolecular biomaterials for intracellular delivery in theranostics.
细胞利用自然超分子组装来维持内稳态和生物功能。现在，人们正在利用受自然启发的生物材料模块化组装来理解或操纵细胞生物学，以用于治疗、诊断和检测疾病。超分子生物材料，特别是肽和寡核苷酸，可以被精确地调整为具有不同的结构、机械、物理化学和生物学特性。这些作为构建块的寡核苷酸和肽的优点，促使了许多基于核酸和肽的自组装纳米材料的发展，这些材料可用于各种医学应用，包括药物输送、组织工程、再生医学和免疫疗法。在这篇综述中，我们广泛概述了使用 DNA、RNA 和肽的超分子自组装进行细胞内递药的方法。此外，我们还讨论了与亚细胞递药相关的当前挑战，并对超分子生物材料在治疗学中的细胞内递药应用的未来前景进行了展望。
Zotero 插件
