Nagoshi Narihito, Tsuji Osahiko, Nakamura Masaya, Okano Hideyuki
Department of Orthopaedic Surgery, Keio University School of Medicine, Japan.
Department of Physiology, Keio University School of Medicine, Japan.
Regen Ther. 2019 Jun 13;11:75-80. doi: 10.1016/j.reth.2019.05.006. eCollection 2019 Dec.
For the past few decades, spinal cord injury (SCI) has been believed to be an incurable traumatic condition, but with recent developments in stem cell biology, the field of regenerative medicine has gained hopeful momentum in the development of a treatment for this challenging pathology. Among the treatment candidates, transplantation of neural precursor cells has gained remarkable attention as a reasonable therapeutic intervention to replace the damaged central nervous system cells and promote functional recovery. Here, we highlight transplantation therapy techniques using induced pluripotent stem cells to treat SCI and review the recent research giving consideration to future clinical applications.
在过去几十年里，脊髓损伤（SCI）一直被认为是一种无法治愈的创伤性疾病，但随着干细胞生物学的最新发展，再生医学领域在开发针对这一具有挑战性病理状况的治疗方法方面获得了充满希望的动力。在候选治疗方法中，神经前体细胞移植作为一种合理的治疗干预手段，用以替代受损的中枢神经系统细胞并促进功能恢复，已受到显著关注。在此，我们重点介绍使用诱导多能干细胞治疗脊髓损伤的移植治疗技术，并回顾近期的研究，同时考虑未来的临床应用。
