Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology , Tianjin University , Tianjin 300072 , China.
School of Precision Instruments and Optoelectronics Engineering , Tianjin University , Tianjin 300072 , China.
Mol Pharm. 2019 Aug 5;16(8):3489-3501. doi: 10.1021/acs.molpharmaceut.9b00332. Epub 2019 Jun 27.
Recently, multifunctional clearable inorganic theranostic nanoparticles have been attracting more and more attention. Protein-based nanoparticles can be cleared by the hepatobiliary system efficiently. In this work, ultrasmall gadolinium oxide (GdO) nanoparticles, which possess the advantage of high longitudinal relaxation rate, were coated with bovine serum albumin (BSA). After the GdO/BSA nanoparticles were linked with two-dimensional photothermal MoS nanomaterials, the nanoparticles were also modified with hyaluronic acid (HA) through the disulfide bonds for tumor-targeting effect. As indicated by in vitro and in vivo studies, these GdO/BSA@MoS-HA nanoparticles could be rapidly degraded and excreted after reacting with glutathione (GSH) by the redox response, thus avoiding long-term toxicity. In addition, the cellular uptake study and in vivo multispectral optoacoustic tomography (MSOT), X-ray computed tomography (CT), and magnetic resonance (MR) triple-modal images demonstrated that GdO/BSA@MoS-HA nanoparticles exhibited a high tumor uptake effect after intravenous injection. Consequently, such clearable theranostic nanoparticles with multiple functions, which are applicable in multimodal imaging-guided cancer therapy, might show promise for applications in nanomedical science.
最近，多功能可清除无机治疗纳米粒子引起了越来越多的关注。基于蛋白质的纳米粒子可以被肝胆系统有效地清除。在这项工作中，具有高纵向弛豫率优势的超小氧化钆（GdO）纳米粒子被牛血清白蛋白（BSA）包裹。在 GdO/BSA 纳米粒子与二维光热 MoS 纳米材料连接后，通过二硫键将纳米粒子进一步修饰上透明质酸（HA），以获得肿瘤靶向效果。体外和体内研究表明，这些 GdO/BSA@MoS-HA 纳米粒子可以通过氧化还原反应与谷胱甘肽（GSH）反应后迅速降解和排泄，从而避免长期毒性。此外，细胞摄取研究和体内多光谱光声断层扫描（MSOT）、X 射线计算机断层扫描（CT）和磁共振（MR）三模态图像表明，静脉注射后，GdO/BSA@MoS-HA 纳米粒子表现出很高的肿瘤摄取效果。因此，这种具有多功能的可清除治疗纳米粒子，适用于多模态成像引导的癌症治疗，可能在纳米医学领域有很好的应用前景。
