Marrangoni A G, Marcelli G, Culig M, Simone S T
Surgical Research Laboratory, Mercy Hospital, Pittsburgh, Pennsylvania 15219.
Am J Surg. 1988 Feb;155(2):258-62. doi: 10.1016/s0002-9610(88)80709-8.
The patency of microvascular grafts depends on the luminal diameter, which is determined by the amount of fibrin and platelets deposited on the intraluminal surface and the anastomotic site, and the extent of pseudointimal formation. An experimental microvascular model in rats has been developed in our laboratory using Indium-111-labeled platelets to measure the amount of deposition on grafts inserted into the infrarenal aorta. This study was designed to assess the patency rates in these grafts and the pathologic maturation as determined by light and electron microscopy. Our study suggests that substantial patency rates can be achieved in aspirin-treated rats, although there was little influence on the pathologic maturation. Indium-111 oxine-labeled platelets can be used to document platelet aggregation, and the technique can be a valuable adjunct in the study of microvascular grafts.
微血管移植物的通畅性取决于管腔直径，而管腔直径由沉积在管腔内表面和吻合部位的纤维蛋白和血小板数量以及假内膜形成的程度决定。我们实验室已开发出一种大鼠微血管实验模型，使用铟 - 111标记的血小板来测量插入肾下腹主动脉的移植物上的沉积量。本研究旨在评估这些移植物的通畅率以及通过光镜和电镜确定的病理成熟情况。我们的研究表明，阿司匹林治疗的大鼠可实现较高的通畅率，尽管对病理成熟影响不大。铟 - 111 氧肟酸盐标记的血小板可用于记录血小板聚集，该技术在微血管移植物研究中可能是一种有价值的辅助手段。
