Suga K, Nishigauchi K, Kume N, Kishimoto K, Matsunaga N, Fujioka K, Zempo N, Kensuke E
Department of Radiology, Yamaguchi University School of Medicine, Japan.
Clin Nucl Med. 1998 Jun;23(6):365-9. doi: 10.1097/00003072-199806000-00006.
The effects of a recently synthesized anti-platelet aggregation drug (E-5510) on platelet deposition in a knitted Dacron aortic graft underwent preliminary evaluation by In-111 oxime labeled platelet imaging. Seven patients undergoing aortofemoral bypass using this graft for occlusive disease were randomized into two groups: those receiving E-5510 and those receiving no medication. This agent was administered for 17 days postoperatively, and on the 14th day In-111 platelets were injected and images were acquired at 24, 48, and 72 hours. Platelet deposits in the grafts were assessed by the ratios of graft radioactivity to that of the adjacent native iliac arteries. Platelet deposition at the sites of anastomosis and deposition along the entire graft were normalized by initial deposition at 24 hours, and had significantly decreased at 72 hours in the three treated patients, while the normalized deposition increased progressively over time in the remaining four nonmedicated patients. E-5510 seems to have the potential to inhibit excessive platelet deposition on recently implanted grafts.
一种最近合成的抗血小板聚集药物（E - 5510）对针织涤纶主动脉移植物中血小板沉积的影响，通过铟 - 111肟标记血小板成像进行了初步评估。七名因闭塞性疾病使用这种移植物进行主-股动脉旁路移植术的患者被随机分为两组：一组接受E - 5510治疗，另一组不接受任何药物治疗。该药物在术后使用17天，在第14天注射铟 - 111标记的血小板，并在24、48和72小时采集图像。通过移植物放射性与相邻天然髂动脉放射性的比值评估移植物中的血小板沉积情况。吻合部位的血小板沉积以及沿整个移植物的沉积情况，以24小时时的初始沉积情况进行归一化处理，在三名接受治疗的患者中，72小时时沉积情况显著下降，而其余四名未接受药物治疗的患者中，归一化后的沉积情况随时间逐渐增加。E - 5510似乎有抑制血小板在近期植入移植物上过度沉积的潜力。
