Stojanov Aleksandar, Stojanov Jelena, Milosevic Vuk, Malobabic Marina, Stanojevic Goran, Stevic Milos, Djordjevic Gordana
Clinic of Neurology, Clinical Center Nis, Nis, Serbia.
Special Psychiatric Hospital "Gornja Toponica", Nis, Serbia.
Ann Indian Acad Neurol. 2020 Jul-Aug;23(4):510-514. doi: 10.4103/aian.AIAN_551_20. Epub 2020 May 8.
The coronavirus disease 2019 (COVID-19) is the largest pandemic of our times. We wanted to investigate the impact of COVID-19 pandemic on the psychological status, quality of life (QoL) and quality of sleep (QoS) of myasthenia gravis (MG) patients.
Data on the epidemiological and clinical characteristics of MG were collected. We used a self-designed questionnaire (consisting of 12 questions), a revised 15-item Myasthenia Gravis Quality of Life Questionnaire (MGQOL15r), a 36-item health survey of the Medical Outcomes Study Short Form (SF36), Pittsburgh sleep quality index (PSQI), Hamilton scales for the assessment of anxiety (HAM-A), and depression (HAMD) were used. We reassessed patients who were tested three years ago using the same questionnaires.
The study included 64 MG patients. We noticed a statistically significant difference between the results obtained three years ago and the results from April 2020 in PSQI scores ( < 0.01). MGQOL15r, SF36, and PSQI scores correlate with severe clinical manifestation, high scores on HAM-A and HAM-D ( < 0.01). Higher scores on HAM-D and fear that MG symptoms will be worse if the patient gets an upper respiratory infection were independent predictors of the lower SF36 scores. Regarding MGQOL15r-independent predictors of the higher score were higher scores on HAM-D.
There is a significant impact of the COVID-19 epidemic on the psychological status and especially on the quality of sleep of MG patients. Healthcare organizations need to provide professional therapeutic advice and psychosocial support for this population of patients during the pandemic.
2019年冠状病毒病（COVID-19）是我们这个时代最大的流行病。我们想调查COVID-19大流行对重症肌无力（MG）患者心理状态、生活质量（QoL）和睡眠质量（QoS）的影响。
收集MG的流行病学和临床特征数据。我们使用了自行设计的问卷（由12个问题组成）、修订后的15项重症肌无力生活质量问卷（MGQOL15r）、医学结果研究简表36项健康调查（SF36）、匹兹堡睡眠质量指数（PSQI）、汉密尔顿焦虑评定量表（HAM-A）和汉密尔顿抑郁评定量表（HAMD）。我们使用相同问卷对三年前接受检测的患者进行重新评估。
该研究纳入了64例MG患者。我们注意到三年前获得的结果与2020年4月的结果在PSQI评分上存在统计学显著差异（<0.01）。MGQOL15r、SF36和PSQI评分与严重临床表现、HAM-A和HAM-D高分相关（<0.01）。HAM-D高分以及担心患者上呼吸道感染会使MG症状加重是SF36低分的独立预测因素。关于MGQOL15r，高分的独立预测因素是HAM-D高分。
COVID-19疫情对MG患者的心理状态，尤其是睡眠质量有显著影响。在疫情期间，医疗保健机构需要为这类患者群体提供专业的治疗建议和心理社会支持。
