蓝光疗法可减轻严重创伤性脑损伤幸存者的疲劳：一项随机对照试验。
Blue-Enriched White Light Therapy Reduces Fatigue in Survivors of Severe Traumatic Brain Injury: A Randomized Controlled Trial.
机构信息
Sleep and Clinical Neurophysiology Units, Department of Physiology (Drs Quera Salva, Azabou, Hartley, Sauvagnac, and Leotard), INSERM CIC1429 (Ms Vaugier and Dr Barbot), Department of Physical Medicine and Rehabilitation (Drs Vallat-Azouvi and Azouvi), Laboratory of Psychopathology and Neuropsychology, EA 2027, University Paris 8, Saint-Denis and Antenne UEROS-UGECAMIF (Dr Vallat-Azouvi), Raymond-Poincaré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Garches, France; EA 4047 HANDIReSP, University of Versailles Saint Quentin (UVSQ), Garches, France (Drs Quera Salva, Azabou, Hartley, Sauvagnac, Leotard, and Azouvi); Department of Physical Medicine and Rehabilitation, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France (Dr Pradat Diehl); and Université Pierre et Marie Curie, Paris, France (Dr Pradat Diehl).
出版信息
J Head Trauma Rehabil. 2020 Mar/Apr;35(2):E78-E85. doi: 10.1097/HTR.0000000000000500.
OBJECTIVE
Fatigue is one of the disabling sequelae of traumatic brain injury (TBI), with repercussions on quality of life, rehabilitation, and professional reintegration. Research is needed on effective interventions. We evaluated efficacy of blue-enriched white light (BWL) therapy on fatigue of patients with severe TBI.
SETTING
Physical Medicine and Rehabilitation and Physiology departments of University hospitals.
PARTICIPANTS
Adult patients with fatigue symptoms following severe TBI, Fatigue Severity Scale (FSS) score 4 or more, Epworth Sleepiness Scale (ESS) score 10 or more, and/or Pittsburgh Sleep Quality Index (PSQI]) more than 5 were randomly assigned to one of 2 parallel groups: a BWL therapy group, with 30-minute exposure to waking white light enriched with blue for 4 weeks, and a group without light therapy (N-BWL), no light.
DESIGN
Randomized controlled trial. ClinicalTrials.gov number: NCT02420275.
MAIN MEASURES
The primary outcome measure was the response of the FSS to 4 weeks of treatment. In addition, we assessed latency change of the P300 component of event-related potentials before and after therapy.
RESULTS
Significant improvement in the FSS score (P = .026) was found in the BWL group compared with the N-BWL group.
CONCLUSION
BWL phototherapy reduces fatigue in patients with severe TBI.
目的
疲劳是创伤性脑损伤（TBI）的一种致残后遗症，对生活质量、康复和职业再融入都有影响。需要研究有效的干预措施。我们评估了富含蓝光的白光（BWL）疗法对严重 TBI 后疲劳患者的疗效。
环境
大学医院的物理医学与康复科和生理学系。
参与者
患有严重 TBI 后出现疲劳症状、疲劳严重程度量表（FSS）评分≥4 分、Epworth 嗜睡量表（ESS）评分≥10 分和/或匹兹堡睡眠质量指数（PSQI）≥5 分的成年患者被随机分配到 2 个平行组之一：BWL 治疗组，接受 4 周、每天 30 分钟的富含蓝光的清醒白光照射，和不进行光照治疗的 N-BWL 组。
设计
随机对照试验。临床试验.gov 编号：NCT02420275。
主要观察指标
主要结局指标是 FSS 在 4 周治疗后的反应。此外，我们评估了治疗前后事件相关电位 P300 成分的潜伏期变化。
结果
BWL 组的 FSS 评分有显著改善（P =.026），与 N-BWL 组相比。
结论
BWL 光疗法可减轻严重 TBI 患者的疲劳。
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