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评估肯尼亚艾滋病毒感染者同伴教育者的治疗效果。

Assessing treatment outcomes among peer educators living with HIV in Kenya.

机构信息

Elizabeth Glaser Pediatric AIDS Foundation, Nairobi, Kenya.

Elizabeth Glaser Pediatric AIDS Foundation, Washington DC, United States of America.

出版信息

PLoS One. 2019 Jun 27;14(6):e0218774. doi: 10.1371/journal.pone.0218774. eCollection 2019.

Abstract

BACKGROUND

People living with HIV (PLHIV) often face barriers in accessing quality and comprehensive HIV care, including stigma and discrimination, which results in poor retention and viral non-suppression. Peer-led interventions can help address these barriers. In Kenya, peer educators (PEs) are PLHIV who support other PLHIV to adhere to clinic schedules and antiretroviral medication uptake. In spite of their status as role models and their key role in supporting clients receiving HIV care and treatment, little is known about the characteristics and treatment outcomes of PEs themselves, specifically viral suppression.

METHODS

This is a retrospective descriptive analysis of program data on treatment outcomes of PEs engaged in active patient support activities between October 2010 and January 2017. All eligible PEs from 140 health facilities located in 23 counties of Kenya were included in the study. Data from 230 PEs were abstracted from the electronic medical records, patient files, and registers between June and August 2017. Study variables included key sociodemographic characteristics (sex, marital status, and age), duration on antiretroviral therapy (ART), WHO clinical staging, baseline CD4 count, current antiretroviral regimen and uptake of isoniazid preventive therapy (IPT). The outcome variable was viral suppression, defined as a viral load <1000 copies/ml.

RESULTS

Overall, 173/230 (75%) of the PEs were female, 144/230 (63%) were married, and median age (LQ, UQ) was 38.5 (33.0, 42.0) years. The PEs had been on ART for a median (LQ, UQ) duration of 76.0 (37.0, 105.0) months. Six months IPT completion was high at 97%. Of the 222 (97%) PEs with an up-to-date viral load taken within the last one year, 211 (95%) were virally suppressed.

CONCLUSION

Our study showed that peer educators actively engaged in patient support activities have achieved high viral suppression rates.

摘要

背景

艾滋病毒感染者(PLHIV)在获得优质和全面的艾滋病毒护理方面经常面临障碍,包括耻辱和歧视,这导致保留和病毒抑制不良。同伴主导的干预措施可以帮助解决这些障碍。在肯尼亚,同伴教育者(PE)是支持其他 PLHIV 按时就诊和接受抗逆转录病毒药物治疗的 PLHIV。尽管他们是榜样,并且在支持接受艾滋病毒护理和治疗的客户方面发挥着关键作用,但人们对他们自己的特征和治疗结果知之甚少,特别是病毒抑制情况。

方法

这是对 2010 年 10 月至 2017 年 1 月期间参与积极患者支持活动的同伴教育者治疗结果的方案数据进行的回顾性描述性分析。肯尼亚 23 个县 140 个卫生设施的所有符合条件的同伴教育者均纳入本研究。2017 年 6 月至 8 月期间,从电子病历、患者档案和登记处提取了 230 名同伴教育者的数据。研究变量包括主要社会人口统计学特征(性别、婚姻状况和年龄)、抗逆转录病毒治疗(ART)持续时间、世界卫生组织临床分期、基线 CD4 计数、当前抗逆转录病毒方案和异烟肼预防治疗(IPT)的采用情况。结局变量是病毒抑制,定义为病毒载量<1000 拷贝/ml。

结果

总体而言,230 名同伴教育者中,173 名(75%)为女性,144 名(63%)已婚,中位年龄(LQ,UQ)为 38.5(33.0,42.0)岁。同伴教育者接受 ART 的中位(LQ,UQ)时间为 76.0(37.0,105.0)个月。在过去一年中,有 97%的 222 名(97%)有最新的病毒载量检测记录,其中 211 名(95%)病毒抑制。

结论

我们的研究表明,积极参与患者支持活动的同伴教育者已经实现了高病毒抑制率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d26/6597086/fdcab3d5ea8e/pone.0218774.g001.jpg

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