尿液中低S-腺苷甲硫氨酸/S-腺苷高半胱氨酸比值与慢性肾脏病相关。
Low S-adenosylmethionine/ S-adenosylhomocysteine Ratio in Urine is Associated with Chronic Kidney Disease.
作者信息
Kruglova Maria Petrovna, Grachev Sergej Vital'evich, Bulgakova Polina Olegovna, Ivanov Alexander Vladimirovich, Virus Edward Danielevich, Nikiforova Ksenya Alexandrovna, Fedoseev Anatolij Nikolaevich, Savina Galina Dmitrievna, Kubatiev Aslan Amirkhanovich
机构信息
Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of the Russian Federation, Moscow, Russia.
Department of Molecular and Cell Pathophysiology, Institute of General Pathology and Pathophysiology, Moscow, Russia.
出版信息
Lab Med. 2020 Jan 2;51(1):80-85. doi: 10.1093/labmed/lmz035.
OBJECTIVE
To evaluate the association of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in urine with chronic kidney disease (CKD).
METHODS
Case-control study including 50 patients with CKD and 20 healthy volunteers.
RESULTS
SAM level and SAM/SAH ratio in urine were significantly lower in patients than in control individuals (P <.001 and P = .01, respectively). The estimated glomerular filtration rate was associated with the SAM level (P = .04) and the SAM/SAH ratio in urine (P = .01).
CONCLUSION
CKD is associated not only with the decline in the SAM level but also with the decrease in the SAM/SAH ratio in urine. Thus, use of the urinary SAM/SAH ratio as a noninvasive diagnostic indicator of renal function seems promising.
目的
评估尿中S-腺苷甲硫氨酸（SAM）和S-腺苷同型半胱氨酸（SAH）与慢性肾脏病（CKD）的相关性。
方法
病例对照研究，纳入50例CKD患者和20名健康志愿者。
结果
患者尿中SAM水平和SAM/SAH比值显著低于对照组（分别为P<.001和P =.01）。估计肾小球滤过率与尿中SAM水平（P =.04）及SAM/SAH比值（P =.01）相关。
结论
CKD不仅与SAM水平下降有关，还与尿中SAM/SAH比值降低有关。因此，将尿中SAM/SAH比值用作肾功能的非侵入性诊断指标似乎很有前景。
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