IEEE Trans Biomed Eng. 2020 Mar;67(3):931-937. doi: 10.1109/TBME.2019.2924440. Epub 2019 Jun 24.
Intraocular pressure (IOP) is the leading modifiable risk factor for preventing vision loss in glaucoma patients. Direct and frequent IOP measurements are highly desirable to assess adequacy of treatment and prevent further vision loss. In this study, we report on successful in vivo measurements of intraocular pressure in rabbits using an optical IOP measurement system. The sensor was implanted during cataract surgery in two New Zealand white (NZW) rabbits and tested in vivo for ten weeks. Prior to implantation, the sensors were characterized in vitro in the physiologically relevant pressure range of 0-60 mmHg. A portable wireless handheld reader consisting of an internal beam splitter, a monochromatic light source, and a digital single-lens reflex (DSLR) camera was also designed and implemented to capture interference patterns from the sensor. The sensitivity and accuracy of the sensor was 30 nm/mmHg and ±0.2 mmHg, respectively. Ten weeks post-implantation, the two NZW rabbits continued to respond well to the implant with no observable inflammation, signs of infection, or biofouling. All IOP measurements were obtained using the portable DSLR handheld reader. Successful in vivo studies demonstrate biocompatibility of the IOP sensor and prove feasibility of the IOP measurement system. The system has the potential to be used in both clinical and patient point-of-care (home) settings to frequently and accurately measure pressure.
眼压（IOP）是预防青光眼患者视力丧失的主要可调节风险因素。直接和频繁的 IOP 测量对于评估治疗效果和防止进一步视力丧失非常重要。在这项研究中，我们报告了一种使用光学 IOP 测量系统成功地对兔子进行体内 IOP 测量的情况。该传感器在两只新西兰白兔（NZW）的白内障手术期间植入，并在体内测试了十周。在植入之前，传感器在生理相关的 0-60mmHg 压力范围内进行了体外特性测试。我们还设计并实现了一种由内部分光器、单色光源和数字单镜头反光（DSLR）相机组成的便携式无线手持式读取器，以捕获来自传感器的干涉图案。传感器的灵敏度和精度分别为 30nm/mmHg 和±0.2mmHg。植入十周后，两只 NZW 白兔对植入物的反应仍然良好，没有观察到炎症、感染或生物污损的迹象。所有 IOP 测量均使用便携式 DSLR 手持式读取器获得。体内研究的成功证明了 IOP 传感器的生物相容性，并证明了 IOP 测量系统的可行性。该系统有可能在临床和患者即时护理（家庭）环境中频繁且准确地测量眼压。
