海洋来源真菌 sp. L129 中具有细胞毒性的二聚 1,4-苯醌衍生物。
Dimeric 1,4-benzoquinone Derivatives with Cytotoxic Activities from the Marine-Derived Fungus sp. L129.
机构信息
Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266021, China.
Key Laboratory of Chemical Biology of Ministry of Education, Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
出版信息
Mar Drugs. 2019 Jun 26;17(7):383. doi: 10.3390/md17070383.
Two new dimeric 1,4-benzoquinone derivatives, peniquinone A () and peniquinone B (), a new dibenzofuran penizofuran A (), and a new pyrazinoquinazoline derivative quinadoline D (4), together with 13 known compounds (-), were isolated from a marine-derived fungus sp. L129. Their structures, including absolute configurations, were elucidated by extensive spectroscopic data and electronic circular dichroism calculations. Compound exhibited cytotoxicity against the MCF-7, U87 and PC3 cell lines with IC values of 12.39 µM, 9.01 µM and 14.59 µM, respectively, while compound displayed relatively weak cytotoxicity activities against MCF-7, U87 and PC3 cell lines with IC values of 25.32 µM, 13.45 µM and 19.93 µM, respectively. Furthermore, compound showed weak quorum sensing inhibitory activity against CV026 with an MIC value of 20 μg/well.
从海洋来源真菌 sp. L129 中分离得到两个新的二聚 1,4-苯醌衍生物 peniquinone A () 和 peniquinone B (), 一个新的二苯并呋喃 penizofuran A () 和一个新的吡嗪喹唑啉衍生物 quinadoline D (4), 以及 13 个已知化合物 (-)。通过广泛的光谱数据和电子圆二色性计算确定了它们的结构，包括绝对构型。化合物 对 MCF-7、U87 和 PC3 细胞系表现出细胞毒性，IC 值分别为 12.39 µM、9.01 µM 和 14.59 µM，而化合物 对 MCF-7、U87 和 PC3 细胞系的细胞毒性活性较弱，IC 值分别为 25.32 µM、13.45 µM 和 19.93 µM。此外，化合物 对 CV026 表现出较弱的群体感应抑制活性，MIC 值为 20 μg/孔。
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