从深海来源真菌 NLG-S01-P1 中分离得到具有抗菌和细胞毒性活性的桔青霉素单体和二聚体衍生物。

Key Laboratory of Marine Genetic Resources, State Key Laboratory Breeding Base of Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, Fujian Collaborative Innovation Centre for Exploitation and Utilization of Marine Biological Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China.

Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China.

Mar Drugs. 2019 Jan 10;17(1):46. doi: 10.3390/md17010046.

Two previously unreported citrinin dimer derivatives, penicitol D () and 1--citrinin H1 (), were isolated from the culture of a deep sea-derived fungus NLG-S01-P1, together with 11 biogenetic related compounds (⁻). A plausible biogenetic pathway for compounds ⁻ was proposed. Their structures, including absolute configurations, were established through analysis of extensive spectroscopic data and time-dependent density functional theory (TD-DFT) ECD calculations. Compounds and showed antibacterial activities against methicillin-resistant (MRSA). Compounds and displayed relatively stronger activities than the other compounds against and . Compound showed the most potent cytotoxic activity towards the HeLa cell.

从深海来源真菌 NLG-S01-P1 的培养物中分离得到两个以前未报道的桔青霉素二聚体衍生物，penicitol D () 和 1--桔青霉素 H1 ()，以及 11 个生物合成相关化合物 (⁻)。提出了化合物 ⁻ 的可能生物合成途径。通过分析广泛的光谱数据和时间依赖的密度泛函理论 (TD-DFT) ECD 计算，确定了它们的结构，包括绝对构型。化合物和对耐甲氧西林金黄色葡萄球菌 (MRSA) 具有抗菌活性。化合物和对和的活性均强于其他化合物。化合物对 HeLa 细胞表现出最强的细胞毒性活性。