College of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, Baoding, 071002, China.
College of Life Sciences, Baoding, 071002, China.
Appl Microbiol Biotechnol. 2023 Aug;107(16):5003-5017. doi: 10.1007/s00253-023-12657-3. Epub 2023 Jul 4.
There are many kinds of agricultural pathogenic fungi, which may belong to pathogenic fungi in different species, such as Fusarium, Alternaria, Colletotrichum, Phytophthora, and other agricultural pathogens. Pathogenic fungi from different sources are widely distributed in agriculture, which threaten the lives of crops around the world and caused great damage to agricultural production and economic benefits. Due to the particularity of the marine environment, marine-derived fungi could produce natural compounds with unique structures, rich diversities, and significant bioactivities. Since marine natural products with different structural characteristics could inhibit different kinds of agricultural pathogenic fungi, secondary metabolites with antifungal activity could be used as lead compounds against agricultural pathogenic fungi. In order to summarize the structural characteristics of marine natural products against agricultural pathogenic fungi, this review systematically overview the activities against agricultural pathogenic fungi of 198 secondary metabolites from different marine fungal sources. A total of 92 references published from 1998 to 2022 were cited. KEY POINTS: • Pathogenic fungi, which could cause damage to agriculture, were classified. • Structurally diverse antifungal compounds from marine-derived fungi were summarized. • The sources and distributions of these bioactive metabolites were analyzed.
有许多种农业病原菌真菌，它们可能属于不同种属的病原菌真菌，如镰刀菌、交链孢属、炭疽菌、疫霉属等农业病原菌。不同来源的病原菌真菌广泛分布于农业中，威胁着世界各地作物的生命，给农业生产和经济效益造成了巨大的损失。由于海洋环境的特殊性，海洋来源的真菌能够产生具有独特结构、丰富多样性和显著生物活性的天然化合物。由于具有不同结构特征的海洋天然产物可以抑制不同种类的农业病原菌真菌，因此具有抗真菌活性的次生代谢产物可以用作抗农业病原菌真菌的先导化合物。为了总结海洋天然产物对农业病原菌真菌的结构特征，本综述系统地概述了来自不同海洋真菌来源的 198 种次生代谢产物对农业病原菌真菌的活性。共引用了 1998 年至 2022 年发表的 92 篇参考文献。关键点：
对可能对农业造成破坏的病原菌真菌进行了分类。
总结了海洋来源真菌中具有结构多样性的抗真菌化合物。
分析了这些生物活性代谢物的来源和分布。
