Department of Pathology, Faculty of Medicine, University of Debrecen, Nagyerdei krt 98, Debrecen, H-4032, Hungary.
Department of Oncology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Diagn Pathol. 2024 Jul 26;19(1):103. doi: 10.1186/s13000-024-01529-7.
Extraneural metastasis of central nervous system tumors is generally rare and most often reported in glioblastomas and medulloblastomas, whereas oligodendrogliomas seem to have the lowest risk of extracranial metastasis. Given its infrequent occurrence, both the diagnosis and therapy of metastatic oligodendroglioma is often challenging.
This case study presents an oligodendroglioma, the isocitrate dehydrogenase 1 (IDH1) mutant, 1p/19q-codeleted tumor with bone marrow metastasis. The significance of this case lies in the comprehensive molecular analysis conducted for both the primary tumor and the metastasis. Chromosome 7 trisomy and chromosome 10 monosomy (+ 7/-10) were detected in the metastasis indicating molecular progression, which, to the best of our knowledge, has not been previously documented in metastatic oligodendroglioma.
This case study serves additional information for better understanding of the metastatic capabilities of CNS tumors.
中枢神经系统肿瘤的颅外转移较为罕见，最常发生于胶质母细胞瘤和髓母细胞瘤，而少突胶质细胞瘤的颅外转移风险似乎最低。由于其罕见的发生，转移性少突胶质细胞瘤的诊断和治疗常常具有挑战性。
本病例研究介绍了一例伴有骨髓转移的异柠檬酸脱氢酶 1（IDH1）突变、1p/19q 联合缺失的少突胶质细胞瘤。该病例的意义在于对原发肿瘤和转移灶进行了全面的分子分析。在转移灶中检测到染色体 7 三体和染色体 10 单体性（+7/-10），表明存在分子进展，据我们所知，这在转移性少突胶质细胞瘤中尚未有报道。
本病例研究为更好地了解中枢神经系统肿瘤的转移能力提供了更多信息。
