TRIO Fertility, Toronto, Ontario, Canada; IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
TRIO Fertility, Toronto, Ontario, Canada.
Fertil Steril. 2019 Sep;112(3):503-509.e1. doi: 10.1016/j.fertnstert.2019.05.001. Epub 2019 Jun 24.
To evaluate whether the change in endometrial thickness between the end of the estrogen phase and the day of embryo transfer has an impact on the pregnancy rate in frozen-thawed embryo transfer (FET) cycles.
Retrospective observational cohort study.
Single tertiary care medical center.
PATIENT(S): Ultrasound images in 274 FET cycles were reviewed. All patients underwent endometrial preparation with the use of hormonal therapy.
INTERVENTIONS(S): Ultrasound measurements of endometrial thickness at the end of the estrogen phase and the day of embryo transfer.
MAIN OUTCOME MEASURE(S): The change in endometrial thickness and ongoing pregnancy rate.
RESULT(S): We calculated the ongoing pregnancy rate in patients whose endometrial thickness decreased (compacted) after starting progesterone by 5%, 10%, 15%, or 20% compared with patients with no change or increased endometrial thickness. The ongoing pregnancy rate was significantly increased at all levels of compaction compared with no compaction. The ongoing pregnancy rate showed a significant increase with each decreasing quartile of change in thickness (increased percentage of compaction) in the progesterone phase compared with the estrogen phase.
CONCLUSION(S): There is a highly significant inverse correlation between the ongoing pregnancy rate and the change of endometrial thickness between the end of estrogen administration and the day of embryo transfer.
评估冻融胚胎移植（FET）周期中从雌激素阶段结束到胚胎移植日子宫内膜厚度的变化对妊娠率的影响。
回顾性观察性队列研究。
单家三级保健医疗中心。
回顾了 274 个 FET 周期的超声图像。所有患者均接受激素治疗进行子宫内膜准备。
雌激素阶段结束和胚胎移植日的子宫内膜厚度超声测量。
子宫内膜厚度的变化和持续妊娠率。
与子宫内膜厚度无变化或增加的患者相比，我们计算了在开始使用孕激素后子宫内膜厚度减少（致密化） 5%、10%、15%或 20%的患者的持续妊娠率。与无致密化相比，所有致密化水平的持续妊娠率均显著增加。与雌激素阶段相比，孕激素阶段子宫内膜厚度变化（致密化百分比增加）每降低一个四分位数，持续妊娠率均显著增加。
从雌激素给药结束到胚胎移植日，子宫内膜厚度的变化与持续妊娠率呈高度显著负相关。
