Reproductive Medical Center, Henan Province Key Laboratory for Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, 1# Jianshe East, Zhengzhou, Henan Province, China.
Reprod Biol Endocrinol. 2019 Nov 25;17(1):99. doi: 10.1186/s12958-019-0545-0.
The aim of this study was to explore the impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst.
This observational cohort study included a total of 3091 patients undergoing their first frozen-thawed embryo transfer (FET) cycles between April 2015 to March 2019. Endometrial thickness was measured by trans-vaginal ultrasound twice for each patient: on day of progesterone administration, and on day of embryo transfer. The change of endometrial thickness was recorded.
Regardless of endometrial preparation protocol (estrogen-progesterone/natural cycle), female age, body mass index (BMI), and infertility diagnosis were comparable between patients with an increasing endometrium on day of embryo transfer and those without. However, clinical pregnancy rate increases with increasing ratio of endometrial thickness. Compared with patients with Non-increase endometrium, those with an increasing endometrium on day of embryo transfer resulted in significantly higher clinical pregnancy rate (56.21% vs 47.13%, P = 0.00 in estrogen-progesterone cycle; 55.15% vs 49.55%, P = 0.00 in natural cycle).
In most patients, endometrial thickness on day of embryo transfer (after progesterone administration) increased or kept being stable compared with that on day of progesterone administration. An increased endometrium after progesterone administration was associated with better pregnancy outcome.
本研究旨在探讨接受单个冻融囊胚移植的患者在孕激素治疗后子宫内膜厚度变化对妊娠结局的影响。
本观察性队列研究纳入了 2015 年 4 月至 2019 年 3 月期间进行首次冻融胚胎移植（FET）周期的 3091 名患者。每位患者均通过经阴道超声进行两次子宫内膜厚度测量：孕激素给药日和胚胎移植日。记录子宫内膜厚度的变化。
无论子宫内膜准备方案（雌激素-孕激素/自然周期）、女性年龄、体质量指数（BMI）和不孕诊断如何，在胚胎移植日子宫内膜增加的患者和无增加的患者之间均无差异。然而，临床妊娠率随子宫内膜厚度增加比例的增加而增加。与非增加子宫内膜的患者相比，胚胎移植日子宫内膜增加的患者临床妊娠率显著更高（雌激素-孕激素周期中为 56.21%比 47.13%，P=0.00；自然周期中为 55.15%比 49.55%，P=0.00）。
在大多数患者中，与孕激素给药日相比，胚胎移植日（孕激素治疗后）的子宫内膜厚度增加或保持稳定。孕激素治疗后子宫内膜增加与更好的妊娠结局相关。
