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当代高龄(70 岁以上)与低龄(70 岁以下)人群行根治性前列腺切除术的趋势和尿控恢复的预测因素比较。

Contemporary trends in radical prostatectomy and predictors of recovery of urinary continence in men aged over 70 years: comparisons between cohorts aged over 70 and less than 70 years.

机构信息

Department of Urology, Seoul National University Bundang Hospital, Seongnam 13620, Korea.

Department of Urology, Catholic Kwandong Univerisity International St. Mary's Hospital, Incheon 22711, Korea.

出版信息

Asian J Androl. 2020 May-Jun;22(3):280-286. doi: 10.4103/aja.aja_62_19.

DOI:10.4103/aja.aja_62_19
PMID:31249271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7275794/
Abstract

We evaluated contemporary trends in radical prostatectomy (RP) in men aged >70 years and investigated associations of selected variables with recovery of urinary continence (UC) in two age groups: >70 and ≤ 70 years. A retrospective cohort of 2301 eligible patients attending our institution from 2004 to 2015 was reviewed. Patients were divided into two groups based on age at surgery (>70 years [n = 610] vs 70 years [n = 1691]) and four groups by year of surgery. Over the study period, the proportion of patients aged >70 years gradually increased up to 30.0%, and the rate of robot-assisted RP and neurovascular bundle (NVB) saving increased continually to 80.0% and 67.4% of older patients, respectively. Although the rate of recovery of UC within 12 months (3 months) in patients aged >70 years was lower than that in those aged ≤ 70 years (81.5% [52.6%] vs 88.6% [60.9%], respectively; both P < 0.001), the gap between age groups in the rate of recovery within 12 months narrowed from the second quarter of the study period. Among younger patients, age, robot-assisted RP, prostate volume, membranous urethral length (MUL), and NVB saving were predictors of recovery of UC within 3 or 12 months. In contrast, only age and MUL were predictors of recovery of UC within 3 and 12 months in patients aged >70 years. Therefore, unlike younger patients, only variables (age and MUL), possibly associated with the inherent function of the urinary sphincter, were predictors of recovery of UC in patients aged >70 years.

摘要

我们评估了>70 岁男性接受根治性前列腺切除术(RP)的当代趋势,并研究了两个年龄组(>70 岁和≤70 岁)中选定变量与尿控(UC)恢复之间的关联。我们回顾了 2004 年至 2015 年在我们机构就诊的 2301 名符合条件的患者的回顾性队列。根据手术时的年龄(>70 岁[610 例]与 70 岁[1691 例])将患者分为两组,并按手术年份分为四组。在研究期间,>70 岁患者的比例逐渐增加至 30.0%,机器人辅助 RP 和神经血管束(NVB)保存的比例分别持续增加至 80.0%和 67.4%。尽管>70 岁患者术后 12 个月(3 个月)UC 恢复率低于≤70 岁患者(分别为 81.5%[52.6%]和 88.6%[60.9%];均<0.001),但两组间 12 个月内 UC 恢复率的差距在研究期间的第二个季度缩小。在年轻患者中,年龄、机器人辅助 RP、前列腺体积、膜状尿道长度(MUL)和 NVB 保存是术后 3 个月或 12 个月 UC 恢复的预测因素。相比之下,只有年龄和 MUL 是>70 岁患者术后 3 个月和 12 个月 UC 恢复的预测因素。因此,与年轻患者不同,只有可能与尿括约肌固有功能相关的变量(年龄和 MUL)是>70 岁患者 UC 恢复的预测因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/7275794/59d91a877655/AJA-22-280-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/7275794/81da3ed31d70/AJA-22-280-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/7275794/6aa7ec0a6310/AJA-22-280-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/7275794/fafe982013a1/AJA-22-280-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/7275794/59d91a877655/AJA-22-280-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/7275794/81da3ed31d70/AJA-22-280-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/7275794/6aa7ec0a6310/AJA-22-280-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/7275794/fafe982013a1/AJA-22-280-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1148/7275794/59d91a877655/AJA-22-280-g004.jpg

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