Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, 13620, Korea.
Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, 03080, Korea.
BMC Urol. 2021 Nov 17;21(1):160. doi: 10.1186/s12894-021-00926-0.
Although red blood cells (RBC) transfusion is known to be significantly associated with biochemical recurrence in patients undergoing open prostatectomy, its influence on biochemical recurrence after robot-assisted laparoscopic radical prostatectomy remains unclear. Therefore, this study aimed to validate the effect of RBC transfusion on the 5-year biochemical recurrence in patients undergoing robot-assisted laparoscopic radical prostatectomy.
This study retrospectively analyzed the medical records of patients who underwent robot-assisted laparoscopic radical prostatectomy at single tertiary academic hospital between October 2007 and December 2014. Univariate and multivariate Cox proportional hazard regression analysis was performed to identify any potential variables associated with 5-year biochemical recurrence.
A total of 1311 patients were included in the final analysis. Of these, 30 patients (2.3%) were transfused with RBC either during robot-assisted laparoscopic radical prostatectomy or during their hospital stay, which corresponded to 5-year biochemical recurrence of 15.7%. Multivariate Cox proportional hazard regression analysis showed that RBC transfusion had no influence on the 5-year biochemical recurrence. Variables including pathologic T stage (Hazard ratio [HR] 3.5, 95% confidence interval [CI] 2.4-5.1 p < 0.001), N stage (HR 2.3, 95% CI 1.5-3.7, p < 0.001), Gleason score (HR 2.4, 95% CI 1.8-3.2, p < 0.001), and surgical margin (HR 2.0, 95% CI 1.5-2.8, p < 0.001) were independently associated with the 5-year biochemical recurrence.
RBC transfusion had no significant influence on the 5-year biochemical recurrence in patients undergoing robot-assisted laparoscopic radical prostatectomy.
尽管输血与接受开放式前列腺切除术的患者的生化复发显著相关，但输血对机器人辅助腹腔镜根治性前列腺切除术患者的生化复发的影响尚不清楚。因此，本研究旨在验证输血对机器人辅助腹腔镜根治性前列腺切除术患者 5 年生化复发的影响。
本研究回顾性分析了 2007 年 10 月至 2014 年 12 月在单所三级学术医院接受机器人辅助腹腔镜根治性前列腺切除术的患者的病历。采用单因素和多因素 Cox 比例风险回归分析确定与 5 年生化复发相关的任何潜在变量。
最终分析共纳入 1311 例患者。其中，30 例（2.3%）在机器人辅助腹腔镜根治性前列腺切除术或住院期间接受了 RBC 输血，对应 5 年生化复发率为 15.7%。多因素 Cox 比例风险回归分析显示，输血对 5 年生化复发无影响。包括病理 T 分期（危险比 [HR] 3.5，95%置信区间 [CI] 2.4-5.1，p < 0.001）、N 分期（HR 2.3，95% CI 1.5-3.7，p < 0.001）、Gleason 评分（HR 2.4，95% CI 1.8-3.2，p < 0.001）和手术切缘（HR 2.0，95% CI 1.5-2.8，p < 0.001）等变量与 5 年生化复发独立相关。
输血对机器人辅助腹腔镜根治性前列腺切除术患者的 5 年生化复发无显著影响。
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