1例氨苯砜诱发的高铁血红蛋白血症。
A case of DAPSONE INDUCED METHEMOGLOBINEMIA.
作者信息
Mahmood Najia, Khan Mutti Ullah, Haq Ihtisham U L, Jelani Farhat Afshan, Tariq Aayesha
机构信息
1FCPS Medicine, Holy Family Hospital, Rawalpindi Medical University and Allied Hospitals, Rawalpindi, Pakistan.
FCPS Anesthesia, Combined Military Hospital, Sargodha, Pakistan.
出版信息
J Pharm Policy Pract. 2019 Jun 20;12:22. doi: 10.1186/s40545-019-0185-y. eCollection 2019.
Methemoglobinemia (MetHb) being a rare cause of cyanosis is generally not considered in its differential diagnosis. Methemoglobinemia is an abnormal Hb produced physiologically by auto-oxidation. If this process of auto oxidation is impaired either due to genetic defect or due to exogenous drugs/ toxins, its level starts rising. Once it is > 3%, tissue hypoxia ensues. Here is a case of dapsone induced MetHb and is reported in a young girl with central cyanosis, and was treated successfully with methylene blue. Methemoglobinemia should be considered in differential diagnoses of cyanosed patient with normal ABGs, PaO and cardio-respiratory status. If left untreated, the disease can be fatal.
高铁血红蛋白血症（MetHb）作为发绀的罕见病因，在鉴别诊断中通常不被考虑。高铁血红蛋白血症是由自身氧化生理产生的异常血红蛋白。如果这种自身氧化过程因遗传缺陷或外源性药物/毒素而受损，其水平就会开始上升。一旦超过3%，就会出现组织缺氧。这是一例氨苯砜诱发的高铁血红蛋白血症病例，报道的是一名患有中心性发绀的年轻女孩，用亚甲蓝成功治愈。对于动脉血气分析（ABGs）、动脉血氧分压（PaO）和心肺状态正常的发绀患者，鉴别诊断时应考虑高铁血红蛋白血症。如果不治疗，该病可能致命。
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